{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:26:30Z","timestamp":1789982790178,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>T cell\u2013replete haploidentical stem cell transplantation (haplo\u2010SCT) is a valid therapeutic option for adult patients with high\u2010risk acute myeloid leukemia (AML) lacking an HLA\u2010matched sibling or unrelated donor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We retrospectively analyzed the outcomes of 912 AML patients \u226545 years of age who had undergone haplo\u2010SCT with either myeloablative conditioning (MAC; n\u00a0=\u00a0373) or reduced intensity conditioning (RIC; n\u00a0=\u00a0539) regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median follow\u2010up was 31.1 and 25.7 months for MAC and RIC, respectively. The incidence of relapse and nonrelapse mortality (NRM) were 25.1% versus 28.7% and 31.0% versus 30.3% for MAC and RIC, respectively; 2\u2010year leukemia\u2010free survival (LFS) was 43.9% for MAC versus 41.0% for RIC. In multivariate analysis, the use of MAC versus RIC was not associated with a difference in the outcomes. Results were confirmed in the propensity score\u2013weighted analysis. Disease status and performance status at transplantation were associated with outcomes. Notably, the use of posttransplantation cyclophosphamide was associated with reduced acute graft\u2010versus\u2010host disease (aGVHD) stage III\u2010IV, and NRM and increased overall survival, LFS, and GVHD\u2010free, relapse\u2010free survival. The use of mobilized peripheral blood stem cells was associated with an increased risk of stage II\u2010IV aGVHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>No differences were found between MAC and RIC regimens for haplo\u2010SCT in adults with AML who were \u226545 years of age. The type of GVHD prophylaxis, disease status, and performance status were the major predictors of transplantation outcome. These results may serve as the background for randomized study comparing RIC versus MAC for haplo\u2010SCT in adults with AML.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31941","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T01:42:57Z","timestamp":1546998177000},"page":"1499-1506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Impact of conditioning intensity on outcomes of haploidentical stem cell transplantation for patients with acute myeloid leukemia 45 years of age and over"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5705-8084","authenticated-orcid":false,"given":"Nicole","family":"Santoro","sequence":"first","affiliation":[{"name":"Section of Hematology, Department of Medicine University of Perugia, Centro Ricerche Emato\u2010Oncologiche Perugia 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di Torino Presidio Molinette Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Ehninger","sequence":"additional","affiliation":[{"name":"Universitaets Klinikum Dresden Medizinische Klinik und Poliklinik I Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yener","family":"Koc","sequence":"additional","affiliation":[{"name":"Medical Park Hospitals Stem Cell Transplant Unit Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Santarone","sequence":"additional","affiliation":[{"name":"Ospedale Civile, Dipartimento di Ematologia Medicina Trasfusionale e Biotecnologie Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1906-5819","authenticated-orcid":false,"given":"Xiao\u2010Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital Institute of Haematology 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