{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:13:13Z","timestamp":1791972793999,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["Intramural Research Program"],"award-info":[{"award-number":["Intramural Research Program"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Biliary tract cancers (BTCs) are rare but deadly cancers (gallbladder cancer [GBC], intrahepatic cholangiocarcinoma [ICC], extrahepatic cholangiocarcinoma [ECC], and ampulla of Vater cancer [AVC]). A recent US study reported increasing GBC incidence among people younger than 45 years and blacks; however, it did not examine trends for other biliary tract sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study characterized demographic differences in BTC incidence rates and time trends by anatomic site. Population\u2010based North American Association of Central Cancer Registries data were used to calculate age\u2010adjusted incidence rates, incidence rate ratios (IRRs), and estimated annual percent changes (eAPCs) for 1999\u20102013 by site and demographic group. For sites with significant differences in eAPC by age group, IRRs were compared by age group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GBC incidence rates declined among women (eAPC, \u20130.5%\/y;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01) and all racial\/ethnic groups except for non\u2010Hispanic blacks, among whom rates increased (1.8%\/y;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001). Although GBC rates increased among 18\u2010 to 44\u2010year\u2010olds (eAPC, 1.8%\/y;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01), they decreased among people 45 years old or older (\u20130.4%\/y;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.009). Sex (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001) and racial\/ethnic differences (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.003 to .02) in GBC incidence were larger for younger people than older people. During this period, ICC (eAPC, 3.2%\/y;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001) and ECC rates (1.8%\/y;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001) steadily increased across sex and racial\/ethnic groups. Although AVC incidence rates increased among younger adults (eAPC, 1.8%\/y;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03) but not older adults (\u20130.20%\/y;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.30), sex and racial\/ethnic IRRs did not differ by age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Differential patterns of BTC rates and temporal trends have been identified by anatomic site and demographic groups. These findings highlight the need for large pooling projects to evaluate BTC risk factors by anatomic site.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31942","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T14:45:41Z","timestamp":1547563541000},"page":"1489-1498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":154,"title":["Biliary tract cancer incidence and trends in the United States by demographic group, 1999\u20102013"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8591-9467","authenticated-orcid":false,"given":"Alison L.","family":"Van Dyke","sequence":"first","affiliation":[{"name":"Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith S.","family":"Shiels","sequence":"additional","affiliation":[{"name":"Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gieira S.","family":"Jones","sequence":"additional","affiliation":[{"name":"Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth M.","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Biostatistics Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6580-450X","authenticated-orcid":false,"given":"Jessica L.","family":"Petrick","sequence":"additional","affiliation":[{"name":"Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4320-739X","authenticated-orcid":false,"given":"Jennifer L.","family":"Beebe\u2010Dimmer","sequence":"additional","affiliation":[{"name":"Department of Oncology Wayne State University School of Medicine Detroit Michigan"},{"name":"Population Studies and Disparities Research Program Barbara Ann Karmanos Cancer Institute Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Koshiol","sequence":"additional","affiliation":[{"name":"Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-006-0109-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_8_4_1","volume-title":"Cancer Treatment and Survivorship Facts and Figures, 2016\u20102017","author":"American Cancer Society","year":"2017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt322"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21683"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0199"},{"key":"e_1_2_8_8_1","unstructured":"NAACCR incidence data\u2014CiNA analytic file 1995\u20102013 for expanded races standard file Van Dyke\u2014trends in biliary tract cancer (single age) (which includes data from CDC\u2019s National Program of Cancer Registries (NCPR) CCCR\u2019s provincial and territorial registries and the NCI\u2019s Surveillance Epidemiology and End Results (SEER) registries)."},{"key":"e_1_2_8_9_1","volume-title":"International Classification of Diseases for Oncology","author":"World Health Organization","year":"2000"},{"key":"e_1_2_8_10_1","first-page":"201","article-title":"Histological classification of liver and intrahepatic bile duct cancers in SEER registries","volume":"38","author":"Altekruse SF","year":"2011","journal-title":"J Registry Manag"},{"key":"e_1_2_8_11_1","unstructured":"National Cancer Institute.SEER*Stat software. 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