{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:39:17Z","timestamp":1764603557148,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006384","name":"American College of Radiology Imaging Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006384","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA180820","CA180794","K23-CA187185"],"award-info":[{"award-number":["CA180820","CA180794","K23-CA187185"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,5,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In phase 3 trials of patients with resected high\u2010risk renal cell carcinoma, adjuvant sunitinib has demonstrated no overall survival (OS) benefit, an uncertain disease\u2010free survival (DFS) benefit, and increased toxicity versus placebo. To identify patients who may derive benefit or harm from adjuvant therapy, the authors assessed the effects of age and sex on treatment outcomes in the phase 3 Adjuvant Sorafenib or Sunitinib for Unfavorable Renal Cancer (ASSURE) trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The authors conducted a post hoc subgroup analysis of age and sex among patients in the ASSURE trial. Adjusted hazard ratios (HRs) for OS and DFS were evaluated with sunitinib or sorafenib versus placebo in 4 patient subgroups defined by sex and median age at the time of the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sunitinib treatment was associated with decreased OS (HR, 2.21; 95% confidence interval, 1.29\u20103.80) among women aged &gt;56 years, but not in women aged \u226456 years or men of any age. Similar associations with age and sex were observed for DFS, but these were not statistically significant (women aged &gt;56 years: HR, 1.41 [95% confidence interval, 0.94\u20102.10]). No such association was found for sorafenib. The interaction by age and sex on mortality was found to be statistically significant for sunitinib (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.01), but not sorafenib (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.10).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adjuvant sunitinib may increase mortality among older women with renal cell carcinoma. Given the recent approval of adjuvant sunitinib for patients with high\u2010risk resected renal cell carcinoma, additional studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31955","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T01:46:53Z","timestamp":1546998413000},"page":"1637-1644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Association between age and sex and mortality after adjuvant therapy for renal cancer"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-5356","authenticated-orcid":false,"given":"Ronac","family":"Mamtani","sequence":"first","affiliation":[{"name":"Abramson Cancer Center, Department of Medicine University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin Victoria","family":"Wang","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7444-8594","authenticated-orcid":false,"given":"Bishal","family":"Gyawali","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women's Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"DiPaola","sequence":"additional","affiliation":[{"name":"University of Kentucky College of Medicine Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Neill","family":"Epperson","sequence":"additional","affiliation":[{"name":"Penn PROMOTES Research on Sex and Gender in Health, Department of Psychiatry, Department of Obstetrics and Gynecology University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi B.","family":"Haas","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center, Department of Medicine University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice P.","family":"Dutcher","sequence":"additional","affiliation":[{"name":"Cancer Research Foundation Inc Chappaqua New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00559-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.5324"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1093\/annonc\/mdw667","article-title":"Adjuvant sunitinib for high\u2010risk\u2010resected renal cell carcinoma: a meta\u2010analysis of ASSURE and S\u2010TRAC trials","volume":"28","author":"Gyawali B","year":"2017","journal-title":"Ann Oncol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/509282a"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.3290"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-016-0428-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604456"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061884"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.12.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181fa8efd"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.05.111"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000165572.38887.da"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0258(20001015)19:19<2595::AID-SIM562>3.0.CO;2-M"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056667"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1893"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-009-1170-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.596.65.2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2006.00300.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-017-3268-y"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.07.006"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.20.2441"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09160"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2012.10.012"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-013-1071-x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.5697"},{"key":"e_1_2_8_27_1","unstructured":"European Medicines Association.Withdrawal of application for a change to the marketing authorisation for Sutent (sunitinib).http:\/\/www.ema.europa.eu\/documents\/medicine-qa\/questions-answers-withdrawal-application-change-marketing-authorisation-sutent-sunitinib_en.pdf. 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