{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:59:07Z","timestamp":1770973147985,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CRT48321"],"award-info":[{"award-number":["CRT48321"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["RFA#CA-96-011"],"award-info":[{"award-number":["RFA#CA-96-011"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Having a first\u2010degree relative (FDR) with colorectal cancer (CRC) is a significant risk factor for CRC. Counseling for FDRs regarding CRC risk factors and personalized risk is important to improve knowledge and screening compliance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 3\u2010arm randomized controlled trial compared tailored in\u2010person and telephone CRC counseling interventions with controls among FDRs who were not mutation carriers for known hereditary cancer syndromes, but who were considered to be at an increased risk based on family history. It was hypothesized that both telephone and in\u2010person approaches would increase CRC knowledge, screening adherence, perceived risk accuracy, and psychosocial functioning compared with controls. The authors anticipated greater satisfaction with the in\u2010person approach. CRC knowledge, risk perception, psychosocial functioning, and intention to screen were assessed at baseline and at 2\u2010week and 2\u2010month follow\u2010ups (primary endpoint).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 278 FDRs (mean age, 47.4\u00a0years, standard deviation, 11.38\u00a0years) participated. At baseline, participants reported low to moderate CRC knowledge and overestimations of risk. Screening adherence was 73.7%. At 2\u00a0months, participants in the in\u2010person arm and telephone arm demonstrated improvements in knowledge and perceived risk and were not found to be statistically different from each other. However, when comparing each intervention with controls, knowledge in the in\u2010person arm was found to be statistically significantly higher, but the difference between the telephone and control arms was not. Cancer\u2010related stress reduced over time in all groups. Intervention benefits were maintained at 1\u00a0year. Baseline screening intent\/adherence were high, and therefore did not reach statistically significant improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tailored in\u2010person or telephone formats for providing CRC risk counseling, incorporating behavioral interventions, appear to improve knowledge and risk perceptions, with high client satisfaction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32032","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T15:04:22Z","timestamp":1552403062000},"page":"2272-2282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Telephone versus in\u2010person colorectal cancer risk and screening intervention for first\u2010degree relatives: A randomized controlled trial"],"prefix":"10.1002","volume":"125","author":[{"given":"Mary Jane","family":"Esplen","sequence":"first","affiliation":[{"name":"de Souza Institute University Health Network Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"},{"name":"Psychosocial Oncology and Palliative Care, Princess Margaret Cancer Centre University Health Network Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Harrington","sequence":"additional","affiliation":[{"name":"Psychosocial Oncology and Palliative Care, Princess Margaret Cancer Centre University Health Network Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3348-1547","authenticated-orcid":false,"given":"Yvonne W.","family":"Leung","sequence":"additional","affiliation":[{"name":"de Souza Institute University Health Network Toronto Ontario Canada"},{"name":"Department of 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