{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:33:52Z","timestamp":1789500832674,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Burkitt lymphoma is a fast\u2010growing mature B cell malignancy, whose genetic hallmark is translocation and activation of the c\u2010myc gene. Prompt multiagent immunochemotherapy regimens can have favorable outcomes, but prognosis is poor in refractory or relapsed disease. We previously identified a novel family of near\u2010infrared heptamethine carbocyanine fluorescent dyes (HMCD or DZ) with tumor\u2010homing properties via organic anion\u2010transporting peptides. These membrane carriers have uptake in tumor cells but not normal cells in cell culture, mouse and dog tumor models, patient\u2010derived xenografts, and perfused kidney cancers in human patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here we report the cytotoxic effects of a synthesized conjugate of DZ with cisplatin (CIS) on B cell lymphoma CA46, Daudi, Namalwa, Raji, and Ramos cell lines in cell culture and in xenograft tumor formation. Impaired mitochondrial membrane permeability was examined as the mechanism of DZ\u2010CIS\u2013induced lymphoma cell death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The new conjugate, DZ\u2010CIS, is cytotoxic against Burkitt lymphoma cell lines and tumor models. DZ\u2010CIS retains tumor\u2010homing properties to mitochondrial and lysosomal compartments, does not accumulate in normal cells and tissues, and has no nephrotoxicity in mice. DZ\u2010CIS accumulated in Burkitt lymphoma cells and tumors induces apoptosis and retards tumor cell growth in culture and xenograft tumor growth in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      DZ\u2010CIS downregulated c\u2010myc and overcame CIS resistance in\n                      <jats:italic>myc<\/jats:italic>\n                      \u2010driven TP53\u2010mutated aggressive B cell Burkitt lymphoma. We propose that DZ\u2010CIS could be used to treat relapsed\/refractory aggressive Burkitt lymphomas.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32033","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T13:39:08Z","timestamp":1551879548000},"page":"2222-2232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Targeting Burkitt lymphoma with a tumor cell\u2013specific heptamethine carbocyanine\u2010cisplatin conjugate"],"prefix":"10.1002","volume":"125","author":[{"given":"Stefan","family":"Mrdenovic","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine University Hospital Osijek Osijek Croatia"},{"name":"Department of Medicine Uro\u2010Oncology Research Program, Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Research Institute, Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine Uro\u2010Oncology Research Program, Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Medicine Uro\u2010Oncology Research Program, Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina Chia\u2010Yi","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Medicine Uro\u2010Oncology Research Program, Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Medicine Uro\u2010Oncology Research Program, Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Pathology Veterans Affairs Greater Los Angeles Healthcare System Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Heffer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Biology and Genetics Josip Juraj Strossmayer University of Osijek Osijek Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyen E.","family":"Zhau","sequence":"additional","affiliation":[{"name":"Department of Medicine Uro\u2010Oncology Research Program, Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9445-3569","authenticated-orcid":false,"given":"Leland W. 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