{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:44Z","timestamp":1786977524424,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammatory breast cancer (IBC) is an uncommon and aggressive subtype of breast cancer associated with early disease recurrence and short survival. The prevalence of germline variants in cancer predisposition genes has not been systematically evaluated in women with IBC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among 301 women enrolled in the clinical IBC registry at a single institution between 2010 and 2017, 168 had documented genetic testing. A second cohort of 200 IBC cases who had panel\u2010based germline testing performed through a commercial testing laboratory from 2012 to 2017 was added to the analyses. Personal and family cancer histories and genetic testing results were evaluated when they were available for both cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 501 IBC cases, 368 had documented genetic testing. Germline mutations (56 total) were identified in 53 cases (14.4%).\n                      <jats:italic>BRCA1<\/jats:italic>\n                      or\n                      <jats:italic>BRCA2<\/jats:italic>\n                      mutations were found in 7.3% of the subjects, 6.3% had a mutation in other breast cancer genes (\n                      <jats:italic>PALB2<\/jats:italic>\n                      ,\n                      <jats:italic>CHEK2<\/jats:italic>\n                      ,\n                      <jats:italic>ATM<\/jats:italic>\n                      , and\n                      <jats:italic>BARD1<\/jats:italic>\n                      ), and 1.6% had mutations in genes not associated with breast cancer. The prevalence of mutations was 24% (22 of 92) among women with triple\u2010negative IBC, 13% (13 of 99) among women with estrogen receptor\u2013 and\/or progesterone receptor\u2013positive, human epidermal growth factor receptor 2 (HER2)\u2013negative disease, and 9.3% (10 of 108) among women with HER2\u2010positive IBC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence and diversity of germline genetic mutations among patients with IBC suggest that further studies should be performed to assess the role of inherited mutations in IBC carcinogenesis in comparison with non\u2010IBC breast cancer. Since IBC has a high metastatic potential associated with poor prognostic outcomes, proposed future studies may also inform targeted treatment options.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32062","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T11:10:22Z","timestamp":1554117022000},"page":"2194-2202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prevalence of germline variants in inflammatory breast cancer"],"prefix":"10.1002","volume":"125","author":[{"given":"Huma Q.","family":"Rana","sequence":"first","affiliation":[{"name":"Division of Population Sciences Dana\u2010Farber Cancer Institute Boston Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Sacca","sequence":"additional","affiliation":[{"name":"Division of Population Sciences Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Drogan","sequence":"additional","affiliation":[{"name":"Division of Population Sciences Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Ambry Genetics Aliso Viejo California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Schlosnagle","sequence":"additional","affiliation":[{"name":"Susan F. Smith Center for Women\u2019s Cancers, Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith M.","family":"Regan","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts"},{"name":"Department of Biostatistics and Computational Biology Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4773-9411","authenticated-orcid":false,"given":"Virginia","family":"Speare","sequence":"additional","affiliation":[{"name":"Ambry Genetics Aliso Viejo California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"LaDuca","sequence":"additional","affiliation":[{"name":"Ambry Genetics Aliso Viejo California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Dolinsky","sequence":"additional","affiliation":[{"name":"Ambry Genetics Aliso Viejo California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy E.","family":"Garber","sequence":"additional","affiliation":[{"name":"Division of Population Sciences Dana\u2010Farber Cancer Institute Boston Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"},{"name":"Susan F. Smith Center for Women\u2019s Cancers, Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4438-7000","authenticated-orcid":false,"given":"Beth A.","family":"Overmoyer","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts"},{"name":"Susan F. 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