{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:35:44Z","timestamp":1782880544261,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:00:00Z","timestamp":1555027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,7,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Germline genetic testing currently is recommended for patients with pancreatic ductal adenocarcinoma (PDAC). In the current study, the authors assessed how often results are communicated to first\u2010degree relatives within 3\u00a0months and the emotional impact of testing on patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 148 patients who were newly diagnosed with PDAC and who had undergone testing of 32 cancer susceptibility genes at 3 academic centers were selected; 71% participated. Subjects completed the Multidimensional Impact of Cancer Risk Assessment (MICRA) and a family communication survey. The results of both surveys were assessed at 3\u00a0months according to the genetic test result (positive, negative, or variant of unknown significance [VUS]) and whether a patient met criteria for genetic testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 99 patients completed the MICRA survey and 104 completed the family communication survey. The average age of the patients was 67\u00a0years, 47% were female, 29% had stage III\/IV (AJCC 8th edition) disease, and 42% met genetic testing criteria. Approximately 80% of patients told at least 1 first\u2010degree relative about their result. There was a trend toward greater disclosure among patients who tested positive (93% vs 77% for those with a VUS result [\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.149] and 74% for those who tested negative [\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.069]). Patients not meeting genetic testing criteria were less likely to disclose results (69% vs 93%;\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.003). MICRA scores did not differ by test result, age, stage of disease, or sex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The rate of result communication was high, although it was lower among patients who did not meet genetic testing criteria, those who tested negative, or those who had a VUS result. Testing\u2010associated distress was similar across patient groups, and was comparable to that reported by other patients with cancer. Improved communication for all patients is crucial given the prognosis of PDAC, which limits time for disclosure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32077","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T02:00:20Z","timestamp":1555120820000},"page":"2488-2496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Family communication and patient distress after germline genetic testing in individuals with pancreatic ductal adenocarcinoma"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0905-7583","authenticated-orcid":false,"given":"Mary Linton B.","family":"Peters","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Beth Israel Deaconess Medical Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Stobie","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Beth Israel Deaconess Medical Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Dudley","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Karloski","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Allen","sequence":"additional","affiliation":[{"name":"Division of Clinical Affairs, Division of Bioinformatics Ambry Genetics Aliso Viejo California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4773-9411","authenticated-orcid":false,"given":"Virginia","family":"Speare","sequence":"additional","affiliation":[{"name":"Division of Clinical Affairs, Division of Bioinformatics Ambry Genetics Aliso Viejo California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill S.","family":"Dolinsky","sequence":"additional","affiliation":[{"name":"Division of Clinical Affairs, Division of Bioinformatics Ambry Genetics Aliso Viejo California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Tian","sequence":"additional","affiliation":[{"name":"Division of Clinical Affairs, Division of Bioinformatics Ambry Genetics Aliso Viejo California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"DeLeonardis","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Beth Israel Deaconess Medical Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Krejdovsky","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Beth Israel Deaconess Medical Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene","family":"Button","sequence":"additional","affiliation":[{"name":"HonorHealth Research Institute Scottsdale Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Lim","sequence":"additional","affiliation":[{"name":"HonorHealth Research Institute Scottsdale Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkut","family":"Borazanci","sequence":"additional","affiliation":[{"name":"HonorHealth Research Institute Scottsdale Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall","family":"Brand","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh Medical Center Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Tung","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Beth Israel Deaconess Medical Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.72.3502"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.11.042"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.7401"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29664"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0455"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31628"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.7535"},{"key":"e_1_2_8_10_1","first-page":"1","article-title":"Should we lower our threshold for germline genetic assessment in pancreatic adenocarcinoma?","author":"Schwark AL","year":"2018","journal-title":"JCO Precision Oncol"},{"key":"e_1_2_8_11_1","unstructured":"National Comprehensive Cancer Network.Genetic\/familial high\u2010risk assessment: breast and ovarian version 2.2019.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/genetics_screening.pdf. Accessed July 30 2018."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01489"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-16-1250"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900212"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/gte.2007.0037"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.7541"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000144014.91237.A1"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-015-9894-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1897-4287-5-2-59"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28879"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.1561"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-015-9811-2"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.016"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-018-0145-z"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-017-0090-y"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.435"},{"key":"e_1_2_8_27_1","unstructured":"National Comprehensive Cancer Network.Genetic\/familial high\u2010risk assessement: colorectal version 2.2017.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/genetics_colon_pdf. Accessed August 13 2017."},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.198499"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.1.43"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-017-9661-5"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.21.6.564"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.34.15_suppl.1503"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.137"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-013-9609-z"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10110"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.207"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.32077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.32077","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.32077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:41:45Z","timestamp":1761871305000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.32077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,12]]},"references-count":35,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2019,7,15]]}},"alternative-id":["10.1002\/cncr.32077"],"URL":"https:\/\/doi.org\/10.1002\/cncr.32077","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,12]]},"assertion":[{"value":"2018-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}