{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:01:14Z","timestamp":1778198474575,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000142","name":"Avon Foundation for Women","doi-asserted-by":"publisher","award":["02-2013-044"],"award-info":[{"award-number":["02-2013-044"]}],"id":[{"id":"10.13039\/100000142","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000142","name":"Avon Foundation for Women","doi-asserted-by":"publisher","award":["05-2015-055"],"award-info":[{"award-number":["05-2015-055"]}],"id":[{"id":"10.13039\/100000142","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA054281"],"award-info":[{"award-number":["CA054281"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA063464"],"award-info":[{"award-number":["CA063464"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA164973"],"award-info":[{"award-number":["CA164973"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K24CA169004"],"award-info":[{"award-number":["K24CA169004"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA033572"],"award-info":[{"award-number":["P30CA033572"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA77398"],"award-info":[{"award-number":["R01 CA77398"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA169004"],"award-info":[{"award-number":["R01CA169004"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["RC4A153828"],"award-info":[{"award-number":["RC4A153828"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002027","name":"Lynne Cohen Foundation for Ovarian Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSGT-09-263-01-CCE"],"award-info":[{"award-number":["RSGT-09-263-01-CCE"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,8,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Breast cancer (BC) is the most common cancer and related cause of mortality among Hispanics, yet susceptibility has been understudied.\n                      <jats:italic>BRCA1<\/jats:italic>\n                      and\n                      <jats:italic>BRCA2<\/jats:italic>\n                      (\n                      <jats:italic>BRCA<\/jats:italic>\n                      ) mutations explain less than one\u2010half of hereditary BC, and the proportion associated with other BC susceptibility genes is unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Germline DNA from 1054\n                      <jats:italic>BRCA<\/jats:italic>\n                      \u2010mutation\u2013negative Hispanic women with hereditary BC (BC diagnosed at age &lt;51\u00a0years, bilateral BC, breast and ovarian cancer, or BC diagnosed at ages 51\u201070\u00a0years with \u22652 first\u2010degree or second\u2010degree relatives who had BC diagnosed at age &lt;70\u00a0years), 312 local controls, and 887 multiethnic cohort controls was sequenced and analyzed for 12 known and suspected, high\u2010penetrance and moderate\u2010penetrance cancer susceptibility genes (ataxia telangiectasia mutated [\n                      <jats:italic>ATM<\/jats:italic>\n                      ], breast cancer 1 interacting protein C\u2010terminal helicase 1 [\n                      <jats:italic>BRIP1<\/jats:italic>\n                      ], cadherin 1 [\n                      <jats:italic>CDH1<\/jats:italic>\n                      ], checkpoint kinase 2 [\n                      <jats:italic>CHEK2<\/jats:italic>\n                      ], nibrin [\n                      <jats:italic>NBN<\/jats:italic>\n                      ], neurofibromatosis type 1 [\n                      <jats:italic>NF1<\/jats:italic>\n                      ], partner and localizer of BRCA2 [\n                      <jats:italic>PALB2<\/jats:italic>\n                      ], phosphatase and tensin homolog [\n                      <jats:italic>PTEN<\/jats:italic>\n                      ], RAD51 paralog 3 [\n                      <jats:italic>RAD51C<\/jats:italic>\n                      ],\n                      <jats:italic>RAD51D<\/jats:italic>\n                      , serine\/threonine kinase 11 [\n                      <jats:italic>STK11<\/jats:italic>\n                      ], and\n                      <jats:italic>TP53<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010nine (4.6%) pathogenic or likely pathogenic variants (PVs) in 47 of 1054 participants (4.5%), including 21 truncating frameshift, 20 missense, 5 nonsense, and 4 splice variants, were identified in\n                      <jats:italic>CHEK2<\/jats:italic>\n                      (n\u00a0=\u00a020),\n                      <jats:italic>PALB2<\/jats:italic>\n                      (n\u00a0=\u00a018),\n                      <jats:italic>ATM<\/jats:italic>\n                      (n\u00a0=\u00a05),\n                      <jats:italic>TP53<\/jats:italic>\n                      (n\u00a0=\u00a03),\n                      <jats:italic>BRIP1<\/jats:italic>\n                      (n\u00a0=\u00a02), and\n                      <jats:italic>CDH1<\/jats:italic>\n                      and\n                      <jats:italic>NF1<\/jats:italic>\n                      (both n\u00a0=\u00a01) and none were identified in\n                      <jats:italic>NBN<\/jats:italic>\n                      ,\n                      <jats:italic>PTEN<\/jats:italic>\n                      ,\n                      <jats:italic>STK11<\/jats:italic>\n                      ,\n                      <jats:italic>RAD51C<\/jats:italic>\n                      , or\n                      <jats:italic>RAD51D<\/jats:italic>\n                      . Nine participants carried the\n                      <jats:italic>PALB2<\/jats:italic>\n                      c.2167_2168del PV (0.85%), and 14 carried the\n                      <jats:italic>CHEK2<\/jats:italic>\n                      c.707T&gt;C PV (1.32%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Of 1054\n                      <jats:italic>BRCA<\/jats:italic>\n                      \u2010negative, high\u2010risk Hispanic women, 4.5% carried a PV in a cancer susceptibility gene, increasing understanding of hereditary BC in this population. Recurrent PVs in\n                      <jats:italic>PALB2<\/jats:italic>\n                      and\n                      <jats:italic>CHEK2<\/jats:italic>\n                      represented 47% (23 of 49) of the total, suggesting a founder effect. Accurate classification of variants was enabled by carefully controlling for ancestry and the increased identification of at\u2010risk Hispanics for screening and prevention.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32083","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T14:30:51Z","timestamp":1560781851000},"page":"2829-2836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Pathogenic and likely pathogenic variants in\n                    <i>PALB2<\/i>\n                    ,\n                    <i>CHEK2<\/i>\n                    , and other known breast cancer susceptibility genes among 1054\n                    <i>BRCA<\/i>\n                    \u2010negative Hispanics with breast cancer"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6714-092X","authenticated-orcid":false,"given":"Jeffrey N.","family":"Weitzel","sequence":"first","affiliation":[{"name":"Division of Clinical Cancer Genomics City of Hope Duarte California"},{"name":"Clinical Cancer Genomics Community Research Network Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"Neuhausen","sequence":"additional","affiliation":[{"name":"Division of Biomarkers of Early Detection and Prevention City of Hope Duarte California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Adamson","sequence":"additional","affiliation":[{"name":"Division of Biomarkers of Early Detection and Prevention City of Hope Duarte California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Tao","sequence":"additional","affiliation":[{"name":"Integrative Genomics Core City of Hope Duarte California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charit\u00e9","family":"Ricker","sequence":"additional","affiliation":[{"name":"Clinical Cancer Genomics Community Research Network Los Angeles California"},{"name":"University of Southern California Norris Comprehensive Cancer Center Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7502-3923","authenticated-orcid":false,"given":"Asaf","family":"Maoz","sequence":"additional","affiliation":[{"name":"University of Southern California Norris Comprehensive Cancer Center Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margalit","family":"Rosenblatt","sequence":"additional","affiliation":[{"name":"University of California at San Francisco Helen Diller Family Comprehensive Cancer Center San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bita","family":"Nehoray","sequence":"additional","affiliation":[{"name":"Division of Clinical Cancer Genomics City of Hope Duarte California"},{"name":"Clinical Cancer Genomics Community Research Network Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Sand","sequence":"additional","affiliation":[{"name":"Division of Clinical Cancer Genomics City of Hope Duarte California"},{"name":"Clinical Cancer Genomics Community Research Network Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Steele","sequence":"additional","affiliation":[{"name":"Division of Biomarkers of Early Detection and Prevention City of Hope Duarte California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Unzeitig","sequence":"additional","affiliation":[{"name":"Clinical Cancer Genomics Community Research Network Los Angeles California"},{"name":"Gary Unzeitig MD Office Laredo Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Feldman","sequence":"additional","affiliation":[{"name":"Clinical Cancer Genomics Community Research Network Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amie M.","family":"Blanco","sequence":"additional","affiliation":[{"name":"University of California at San Francisco Helen Diller Family Comprehensive Cancer Center San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donglei","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine University of California at San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Huntsman","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine University of California at San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Castillo","sequence":"additional","affiliation":[{"name":"Division of Clinical Cancer Genomics City of Hope Duarte California"},{"name":"Clinical Cancer Genomics Community Research Network Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Haiman","sequence":"additional","affiliation":[{"name":"Center for Genetic Epidemiology, Department of Preventive Medicine University of Southern California Keck School of Medicine Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Slavin","sequence":"additional","affiliation":[{"name":"Division of Clinical Cancer Genomics City of Hope Duarte California"},{"name":"Clinical Cancer Genomics Community Research Network Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elad","family":"Ziv","sequence":"additional","affiliation":[{"name":"University of California at San Francisco Helen Diller Family Comprehensive Cancer Center San Francisco California"},{"name":"Division of General Internal Medicine, Department of Medicine University of California at San Francisco San Francisco California"},{"name":"University of California at San Francisco Institute for Human Genetics San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Projection of the Size and Composition of the US Population: 2014 to 2060. Current Population Reports, P25\u20101143","author":"Colby SL","year":"2014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.53.4.205"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji064"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00218-1"},{"key":"e_1_2_8_6_1","first-page":"94","article-title":"Genetic cancer risk assessment for breast cancer in Latin America","volume":"69","author":"Chavarri\u2010Guerra Y","year":"2017","journal-title":"Rev Invest Clin"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2270482"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7545954"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8091231"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29058"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3312-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12505"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.0027"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.10.027"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-009-0383-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0072"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00615-3"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.01.010"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115052108"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1501341"},{"key":"e_1_2_8_21_1","unstructured":"National Comprehensive Cancer Network (NCCN).NCCN Guidelines Genetic\/Familial High\u2010Risk Assessment: Breast and Ovarian Version 2.2016. Available at:https:\/\/www.nccn.org\/professionals\/physician_gls\/f_guidelines.asp. Accessed May 10 2016."},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20128"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2010.0046"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp324"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_2_8_27_1","unstructured":"National Comprehensive Cancer Network (NCCN).NCCN Genetic\/Familial High\u2010Risk Assessment: Breast and Ovarian Version 2.2017. Available at:https:\/\/www.nccn.org\/professionals\/physician_gls\/recently_updated.asp. Accessed December 12 2018."},{"key":"e_1_2_8_28_1","unstructured":"1000 Genomes Project.2010. Available at:http:\/\/www.internationalgenome.org\/. Accessed December 12 2018."},{"key":"e_1_2_8_29_1","unstructured":"National Heart Lung and Blood Institute (NHLBI).NHLBI Grand Opportunity Exome Sequencing Project (ESP) 2016. Available at:https:\/\/esp.gs.washington.edu\/drupal\/. Accessed December 12 2018."},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19057"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.3715005"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.097857.109"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks539"},{"key":"e_1_2_8_34_1","unstructured":"Wellcome Sanger Institute.COSMIC: Catalogue of Somatic Mutations in Cancer. Available at:https:\/\/cancer.sanger.ac.uk\/cosmic. Accessed July 13 2016."},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1113"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002554"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31816b5cae"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq603"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1902"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-3981-y"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-017-0024-8"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0424"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.5844"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.5922"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-017-0019-5"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.65.0747"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2017.09.003"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msr049"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11258"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0092"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2039"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27556"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.6480"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.6314"},{"key":"e_1_2_8_56_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology. Version 1.2018: Genetic\/Familial High\u2010Risk Assessment: Breast and Ovarian","author":"National Comprehensive Cancer Network","year":"2018"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.32083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.32083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T23:09:32Z","timestamp":1761865772000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.32083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,17]]},"references-count":55,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2019,8,15]]}},"alternative-id":["10.1002\/cncr.32083"],"URL":"https:\/\/doi.org\/10.1002\/cncr.32083","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,17]]},"assertion":[{"value":"2018-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}