{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:47:00Z","timestamp":1761893220574,"version":"build-2065373602"},"reference-count":123,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,7,15]]},"abstract":"<jats:p>During the period 1884 to 1922, the only option in cases of operable cancers was radical surgery, and only a minority of patients were cured. Sporadic attempts were made to treat inoperable cancer patients with bacterial toxins; however, with the discovery of x\u2010ray and radium, the era of radiation treatment as an alternative to surgery began. The discovery of transmissible cancers and experimental growth of cancer cells offered new information and not only led to a better understanding of the cellular composition of cancers but also yielded important information that ultimately paved the way to chemotherapy. These efforts also advanced the understanding of the pathogenesis of tumors and induced new clinical and pathologic classifications and subspecializations. It is important to emphasize that many of the initiatives and discoveries made in Europe in the second half of the 19th century were first put into clinical practice in the United States during the first 2 decades of the 20th century, including the use of x\u2010ray and radium for irradiation and as diagnostic tools. All things considered, the progress made between 1884 and 1922 came about through the hard work of many eminent individuals; however, there were 7 foresighted pathfinders (3 surgeons, 2 pathologists, 1 internist, and 1 physicist) who\u2014despite their widely diverse backgrounds, personalities, and expertise\u2014made remarkable contributions to oncology to an extent that is still felt today.<\/jats:p>","DOI":"10.1002\/cncr.32086","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T10:18:17Z","timestamp":1555323497000},"page":"2345-2358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pathfinders in oncology from the end of the 19th century to the first description of Ewing sarcoma"],"prefix":"10.1002","volume":"125","author":[{"given":"Steven I.","family":"Hajdu","sequence":"first","affiliation":[{"name":"Pathology Consultants Westlake Village California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"volume-title":"The Timetables of History","year":"1991","author":"Grun B","key":"e_1_2_13_2_1"},{"volume-title":"The Timechart History of Medicine","year":"1999","author":"Davies G","key":"e_1_2_13_3_1"},{"key":"e_1_2_13_4_1","first-page":"420","article-title":"Sur les radiations emises phosphorescence","volume":"122","author":"Becquerel AH","year":"1896","journal-title":"C R H Acad Sci"},{"key":"e_1_2_13_5_1","first-page":"175","article-title":"Sur une substance nouvelle radio\u2010active, contenue dans la pechblende","volume":"127","author":"Curie P","year":"1898","journal-title":"C R H Acad Sci"},{"key":"e_1_2_13_6_1","first-page":"357","article-title":"Zur Kenntniss der anifermentativen lytischen und agglutinierenden Wirzkungen des Blutserum und der Lymph","volume":"27","author":"Landsteiner K","year":"1900","journal-title":"Zbl Bakt"},{"key":"e_1_2_13_7_1","first-page":"471","article-title":"Blood transfusion from antiquity to discovery of the Rh factor","volume":"33","author":"Hajdu SI","year":"2003","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_13_8_1","first-page":"458","article-title":"Mortality from respiratory diseases in dusty trades","volume":"431","author":"Hoffman FL","year":"1918","journal-title":"U. S. Dept Labor Bull"},{"volume-title":"The Peaks of Medical History","year":"1926","author":"Dana CL","key":"e_1_2_13_9_1"},{"volume-title":"Pathfinders in Medicine","year":"1929","author":"Robinson V","key":"e_1_2_13_10_1"},{"volume-title":"Histoire de la Medicine","year":"1931","author":"Castiglioni A","key":"e_1_2_13_11_1"},{"volume-title":"Encyclopedia of Medical Sources","year":"1948","author":"Kelly EC","key":"e_1_2_13_12_1"},{"volume-title":"Contrary to Nature","year":"1977","author":"Shimkin MB","key":"e_1_2_13_13_1"},{"volume-title":"Morton\u2019s Medical Bibliography","year":"1991","author":"Norman JM","key":"e_1_2_13_14_1"},{"key":"e_1_2_13_15_1","first-page":"196","article-title":"Nobel laurate pathologists","volume":"39","author":"Hajdu SI","year":"2009","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31135"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27509"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27889"},{"key":"e_1_2_13_19_1","first-page":"656","article-title":"Amputation du membre superior dans la contiguite du tronc","volume":"9","author":"Berger P","year":"1883","journal-title":"Bull Soc Chir. Paris"},{"key":"e_1_2_13_20_1","first-page":"37","article-title":"Ein Fall von Resektion eines linksseitigen Schnurlappens der Leber","volume":"25","author":"von Langenbuch C","year":"1888","journal-title":"Berl Klin Wosch"},{"key":"e_1_2_13_21_1","first-page":"352","article-title":"On some examples of arsenic\u2010keratosis of the skin and of arsenic cancer","volume":"39","author":"Hutchinson J","year":"1888","journal-title":"Trans Path Soc London"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)29863-3"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01882039"},{"volume-title":"Les Tumeurs de la Vessie","year":"1891","author":"Albarran J","key":"e_1_2_13_24_1"},{"key":"e_1_2_13_25_1","first-page":"211","article-title":"Ueber Lympho\u2010Sarkomatosis","volume":"6","author":"Kundrat H","year":"1893","journal-title":"Wien kiln Wschr"},{"volume-title":"Die Histopathology der Hautkrankheiten","year":"1894","author":"Unna PG","key":"e_1_2_13_26_1"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-189407000-00006"},{"key":"e_1_2_13_28_1","first-page":"507","article-title":"Disarticulation de l\u2019os iliaque poor sarcoma","volume":"75","author":"Girard CH","year":"1894","journal-title":"Lyon Med"},{"key":"e_1_2_13_29_1","first-page":"588","article-title":"Blasengeschwulste bei Fuchsin\u2010Arbeitern","volume":"50","author":"Rehn L","year":"1895","journal-title":"Arch f kiln Chir"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)72307-0"},{"key":"e_1_2_13_31_1","first-page":"14","article-title":"Therapeutische Verwendungen der Rontgenstrahlen","volume":"1","author":"Gocht H","year":"1898","journal-title":"Fortschr Geb Rontg\u2010Strahl"},{"key":"e_1_2_13_32_1","first-page":"433","article-title":"Radium and radio\u2010activity","volume":"10","author":"Abbe R","year":"1904","journal-title":"Yale Med News"},{"volume-title":"Fall af Epitheliom Behandladt med Roentgenstralar","year":"1899","author":"Sjogren TAU","key":"e_1_2_13_33_1"},{"volume-title":"Chirurgie du Rectum","year":"1899","author":"Quene E","key":"e_1_2_13_34_1"},{"key":"e_1_2_13_35_1","first-page":"1","article-title":"Der drusenartige Oberflachenepithelialkrebs","volume":"28","author":"Krompecher E","year":"1900","journal-title":"Beitr path Anat"},{"volume-title":"The Pathology and Surgical Treatment of Tumors","year":"1900","author":"Senn N","key":"e_1_2_13_36_1"},{"key":"e_1_2_13_37_1","first-page":"281","article-title":"Case of splenomedullary leukemia successfully treated by the use of Rontgen ray","volume":"64","author":"Senn N","year":"1903","journal-title":"Med Rep"},{"volume-title":"Die microskopischen Diagnose der bosartigen Geschwulste","year":"1902","author":"von Hansemann DP","key":"e_1_2_13_38_1"},{"key":"e_1_2_13_39_1","first-page":"106","article-title":"Cancroid des rechten handruckens","volume":"6","author":"Frieben E","year":"1902","journal-title":"Fortsh Geb Roentgenstr"},{"key":"e_1_2_13_40_1","first-page":"489","article-title":"Nogle Forsog med Kraeftsvulster","volume":"10","author":"Jensen CO","year":"1902","journal-title":"Hosp Tid Kobenh"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-190210000-00007"},{"volume-title":"Geschwulstlehre fur Arzte und Studierende","year":"1904","author":"Ribbert HWH","key":"e_1_2_13_42_1"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1906.25210220006001a"},{"key":"e_1_2_13_44_1","first-page":"426","article-title":"Karzinoide tumoren des dunndarms","volume":"1","author":"Oberndorfer S","year":"1907","journal-title":"Frankf Z Pathol"},{"volume-title":"Some Points in the Surgery of the Brain and its Membranes","year":"1907","author":"Balance CA","key":"e_1_2_13_45_1"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)99076-7"},{"key":"e_1_2_13_47_1","first-page":"404","article-title":"Contribution a l\u2019etude du developpement des tumeurs malignes sur les ulcers de Roentgen","volume":"3","author":"Marie P","year":"1910","journal-title":"Bull Assoc Francaise Etude Cancer"},{"key":"e_1_2_13_48_1","first-page":"2017","article-title":"Kurze Uebersicht uber meine Erfahrungen mit der Laparo\u2010thorakoskopie","volume":"58","author":"Jacobaeus HC","year":"1911","journal-title":"Munch Med Wochenschr"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.13.5.571"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2015.11.005"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-191209000-00014"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-191212000-00021"},{"key":"e_1_2_13_53_1","first-page":"241","article-title":"Precancerous dermatoses: a study of two cases chronic atypical epithelial proliferation","volume":"30","author":"Bowen JT","year":"1912","journal-title":"J Cutan Dis Syph"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1913.00070050063006"},{"key":"e_1_2_13_55_1","first-page":"614","article-title":"The first successful case of resection of the esophagus for carcinoma","volume":"16","author":"Torek F","year":"1913","journal-title":"Surg Gynecol Obstet"},{"volume-title":"Zur Frage der Entwincklung malignen Tumoren","year":"1914","author":"Boveri T","key":"e_1_2_13_56_1"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1914.02570230019006"},{"key":"e_1_2_13_58_1","first-page":"75","article-title":"Leukosarcomatoese und Myeloblastenleukemie","volume":"61","author":"Sternberg C","year":"1915","journal-title":"Beitr path Anat"},{"key":"e_1_2_13_59_1","first-page":"295","article-title":"Experimentelle Studie uber die Pathogenese der Epitelialgenschwulste","volume":"15","author":"Yamagiwa K","year":"1915","journal-title":"Mitteil Med Facult Kaiser Univ Tokyo"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1917.04270040162007"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1919.26110010018009f"},{"key":"e_1_2_13_62_1","first-page":"369","article-title":"Zur Rontgen\u2010Diagnostik der primaren Lungen Carcinome","author":"Otten","year":"1906","journal-title":"Fort Geb d Rontgenstrah"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-50769-4"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1259\/arr.1914.0140"},{"key":"e_1_2_13_65_1","first-page":"298","article-title":"Radium therapie du cancer du col l\u2019uterus","volume":"22","author":"Degrais P","year":"1915","journal-title":"Ann Gynecol Obstet"},{"key":"e_1_2_13_66_1","first-page":"597","article-title":"Pre\u2010operative and post\u2010operative X\u2010ray in carcinoma of the breast","volume":"7","author":"Quick D","year":"1920","journal-title":"Am J Roentgenol"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-191802000-00015"},{"volume-title":"Pathology of Soft Tissue Tumors","year":"1979","author":"Hajdu SI","key":"e_1_2_13_68_1"},{"key":"e_1_2_13_69_1","first-page":"682","article-title":"Zur Technik und zu den Erfolgen der Magenresection","volume":"23","author":"Kocher T","year":"1893","journal-title":"Correspond f schweiz Aerzte"},{"key":"e_1_2_13_70_1","first-page":"610","article-title":"Zur Magenchirurgie bei Carcinom un bei Ulcus simplex","volume":"28","author":"Kocher T","year":"1898","journal-title":"Correspond f schweiz Aerzte"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02792379"},{"volume-title":"Chirurgische Operationslehre","year":"1892","author":"Kocher T","key":"e_1_2_13_72_1"},{"key":"e_1_2_13_73_1","first-page":"71","article-title":"The operative story of goiter. The author\u2019s operation","volume":"19","author":"Halsted WS","year":"1919","journal-title":"Johns Hopkins Hosp Rep"},{"key":"e_1_2_13_74_1","first-page":"254","article-title":"Uber Kropfextirpation und ihre Folgen","volume":"29","author":"Kocher T","year":"1883","journal-title":"Arch Klin Chir"},{"key":"e_1_2_13_75_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.25100\/cm.v40i2.647","article-title":"Emil Theodor Kocher: an innovator surgeon","volume":"40","author":"Franco ML","year":"2009","journal-title":"Colombia Medica"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02819714"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000201546.94163.00"},{"key":"e_1_2_13_78_1","first-page":"294","article-title":"Practical comments on the use and abuse of cocaine","volume":"42","author":"Halsted WS","year":"1885","journal-title":"N Y Med J"},{"key":"e_1_2_13_79_1","first-page":"255","article-title":"The treatment of wounds with especial reference to the value of the blood clot in the management of dead spaces","volume":"2","author":"Halsted WS","year":"1891","journal-title":"Johns Hopkins Hosp Rep"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM189912281412601"},{"key":"e_1_2_13_81_1","first-page":"297","article-title":"The results of operations for the cure of cancer of the breast performed at the Johns Hopkins Hospital from June 1889 to January 1894","volume":"4","author":"Halsted WS","year":"1895","journal-title":"Johns Hopkins Hosp Rep"},{"key":"e_1_2_13_82_1","first-page":"61","article-title":"The results of radical operations for the cure of cancer of the breast","volume":"25","author":"Halsted WS","year":"1907","journal-title":"Trans Am Surg Assoc"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1915.02570460029011"},{"volume-title":"Wilhelm Conrad Rontgen and the Early History of the Roentgen Rays","year":"1933","author":"Glasser O","key":"e_1_2_13_84_1"},{"key":"e_1_2_13_85_1","first-page":"132","article-title":"Ueber eine neue Art von Strahlen. Vorlaufige Mitteilung","author":"Rontgen WC","year":"1895","journal-title":"Sitzber phys\u2010med Ges Wurzburg"},{"key":"e_1_2_13_86_1","first-page":"11","article-title":"Eine neue Art von Strahlen","author":"Rontgen WC","year":"1896","journal-title":"Sitzber phys\u2010med Ges Wurzburg"},{"key":"e_1_2_13_87_1","first-page":"576","article-title":"Weitere Beobachtungen uber die Eigenschaften der X\u2010Strahlen","author":"Rontgen WC","year":"1897","journal-title":"Sitzber Preuss Akad Wiss Ber Kl Phys\u2010Math"},{"key":"e_1_2_13_88_1","first-page":"199","article-title":"Ueber Uterus\u2010Gonorrhoe","volume":"6","author":"Wertheim E","year":"1895","journal-title":"Verb dtsch Ges Gynak"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02064760"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01910678"},{"key":"e_1_2_13_91_1","first-page":"1","article-title":"The radical abdominal operation in carcinoma of cervix uteri","volume":"4","author":"Wertheim E","year":"1907","journal-title":"Surg Gynec Obst"},{"volume-title":"Die erweiterte abdominale Operation bei Carcinoma colli uteri (auf Grund von 500 Fallen)","year":"1911","author":"Wertheim E","key":"e_1_2_13_92_1"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195609\/10)9:5<859::AID-CNCR2820090502>3.0.CO;2-T"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196610)19:10<1466::AID-CNCR2820191020>3.0.CO;2-7"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1159\/000149583"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02933937"},{"key":"e_1_2_13_97_1","first-page":"166","article-title":"Beitrage zur Kenntniss der granulirten Bindegewebszellen und der eosinophilen Leukocythen","author":"Ehrlich P","year":"1879","journal-title":"Arch Anat Physiol Physiol Abt"},{"volume-title":"Farbenanalytische Untersuchungen zur Histologie und Klinik","year":"1891","author":"Ehrlich P","key":"e_1_2_13_98_1"},{"key":"e_1_2_13_99_1","first-page":"953","article-title":"Uber die Wirkung des Methylenblau bei Malaria","volume":"28","author":"Guttmann P","year":"1891","journal-title":"Berl kiln Wschr"},{"key":"e_1_2_13_100_1","first-page":"299","article-title":"Die Wertbeimessung des Diphterieheilserums un deren theoretische Grundlagen","volume":"6","author":"Ehrlich P","year":"1897","journal-title":"Klin Jahrbuch"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443526"},{"key":"e_1_2_13_102_1","first-page":"2123","article-title":"Die Seitenkettentheorie und ihre Gegner","author":"Ehrlich P","year":"1901","journal-title":"Munchner Med Wochenschr"},{"key":"e_1_2_13_103_1","first-page":"2437","article-title":"Anwendung und Wirkung von Salvarsan","author":"Ehrlich P","year":"1910","journal-title":"Dtsch Med Wochenschr"},{"volume-title":"Beitrage zur Pathologie und Chemotherapy","year":"1909","author":"Ehrlich P","key":"e_1_2_13_104_1"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20908"},{"key":"e_1_2_13_106_1","first-page":"273","article-title":"Francis Peyton Rous","volume":"48","author":"Dulbecco R","year":"1976","journal-title":"J National Acad Sci"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.12.5.696"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.13.4.397"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112160"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.19.1.52"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.60.6.701"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.71.6.787"},{"key":"e_1_2_13_113_1","first-page":"304","article-title":"Noted pathologists and laboratory scientists who attained advanced age","volume":"40","author":"Hajdu SI","year":"2010","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.157.3784.24"},{"key":"e_1_2_13_115_1","first-page":"325","article-title":"Obituaries. James Ewing M.D.","volume":"36","author":"Stewart FW","year":"1943","journal-title":"Arch Path"},{"key":"e_1_2_13_116_1","first-page":"43","article-title":"James Ewing","volume":"26","author":"Murphy JB","year":"1951","journal-title":"National Acad Sci"},{"key":"e_1_2_13_117_1","first-page":"333","article-title":"A case of acute leukemia","volume":"53","author":"Ewing J","year":"1898","journal-title":"Med Rec"},{"volume-title":"Clinical Pathology of the Blood","year":"1901","author":"Ewing J","key":"e_1_2_13_118_1"},{"key":"e_1_2_13_119_1","first-page":"108","article-title":"The enigma of Ewing sarcoma","volume":"36","author":"Hajdu SI","year":"2006","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_13_120_1","first-page":"1","article-title":"Endothelioma of lymph nodes","volume":"28","author":"Ewing J","year":"1913","journal-title":"J Med Res"},{"volume-title":"What We Know About Cancer","year":"1919","author":"Ewing J","key":"e_1_2_13_121_1"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-191903000-00014"},{"key":"e_1_2_13_123_1","first-page":"17","article-title":"Diffuse endothelioma of bone","volume":"21","author":"Ewing J","year":"1921","journal-title":"Proc N Y Path Soc"},{"volume-title":"Causation, Diagnosis and Treatment of Cancer","year":"1931","author":"Ewing J","key":"e_1_2_13_124_1"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.32086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.32086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.32086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:42:13Z","timestamp":1761871333000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.32086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,15]]},"references-count":123,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2019,7,15]]}},"alternative-id":["10.1002\/cncr.32086"],"URL":"https:\/\/doi.org\/10.1002\/cncr.32086","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"type":"print","value":"0008-543X"},{"type":"electronic","value":"1097-0142"}],"subject":[],"published":{"date-parts":[[2019,4,15]]},"assertion":[{"value":"2019-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}