{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:00:51Z","timestamp":1791554451141,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA138292"],"award-info":[{"award-number":["P30CA138292"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,8,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prognostic relevance of human papillomavirus (HPV) status in patients with nonoropharyngeal (OPX) squamous cell cancer (SCC) of the head and neck is controversial. In the current study, the authors evaluated the impact of high\u2010risk HPV status on overall survival (OS) in patients with non\u2010OPX SCC using a large database approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The National Cancer Data Base was queried to identify patients diagnosed from 2004 through 2014 with SCC of the OPX, hypopharynx (HPX), larynx, and oral cavity (OC) with known HPV status. Survival was estimated using Kaplan\u2010Meier methods; distributions were compared using log\u2010rank tests. Propensity score\u2013matching and inverse probability of treatment weighing (IPTW) methods were used; cohorts were matched based on age, sex, Charlson\u2010Deyo score, clinical American Joint Committee on Cancer (AJCC) group stage, treatments received, and anatomic subsite. Propensity analyses were stratified by group stage of disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 24,740 patients diagnosed from 2010 through 2013 were analyzed: 1085 patients with HPX, 4804 with laryngeal, 4,018 with OC, and 14,833 with OPX SCC. The percentages of HPV\u2010positive cases by disease site were 17.7% for HPX, 11% for larynx, 10.6% for OC, and 62.9% for OPX. HPV status was found to be prognostic in multiple unadjusted and propensity\u2010adjusted non\u2010OPX populations. HPV positivity was associated with superior OS in patients with HPX SCC with a hazard ratio (HR) of 0.61 (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\u00a0.001 by IPTW), in patients with AJCC stage III to IVB laryngeal SCC (HR, 0.79;\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.019 by IPTW), and in patients with AJCC stage III to IVB OC SCC (HR, 0.78;\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.03 by IPTW).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Positive high\u2010risk HPV status appears to be associated with longer OS in multiple populations of patients with non\u2010OPX head and neck disease (HPX, locally advanced larynx, and OC). If prospectively validated, these findings have implications for risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32115","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T12:00:48Z","timestamp":1556020848000},"page":"2782-2793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Survival outcomes by high\u2010risk human papillomavirus status in nonoropharyngeal head and neck squamous cell carcinomas: A propensity\u2010scored analysis of the National Cancer Data Base"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5018-4854","authenticated-orcid":false,"given":"Sibo","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Winship Cancer Institute, Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey 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