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Quantifying deaths attributable to cancer can inform priorities to reduce cancer burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Linked transplantation and cancer registry data were used to identify incident cancers and deaths among solid organ transplant recipients in the United States (1987\u20102014). Population\u2010attributable fractions (PAFs) of deaths due to cancer and corresponding cancer\u2010attributable mortality rates were estimated using Cox models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 221,962 solid organ transplant recipients, 15,012 developed cancer. Approximately 13% of deaths (PAF, 13.2%) were attributable to cancer, corresponding to a cancer\u2010attributable mortality rate of 516 per 100,000 person\u2010years. Lung cancer was the largest contributor to mortality (PAF, 3.1%), followed by non\u2010Hodgkin lymphoma (NHL; PAF, 1.9%), colorectal cancer (PAF, 0.7%), and kidney cancer (PAF, 0.5%). Cancer\u2010attributable mortality rates increased with age at transplantation, reaching 1229 per 100,000 person\u2010years among recipients aged \u226565\u00a0years. NHL was the largest contributor among children (PAF, 4.1%) and lung cancer was the largest contributor among recipients aged \u226550\u00a0years (PAFs, 3.7%\u20104.3%). Heart recipients had the highest PAF (16.4%), but lung recipients had the highest cancer\u2010attributable mortality rate (1241 per 100,000 person\u2010years). Overall, mortality attributable to cancer increased steadily with longer time since transplantation, reaching 15.7% of deaths (810 per 100,000 person\u2010years) at \u226510\u00a0years after transplantation. Comparison of cancer\u2010attributable mortality rates with specified causes of death indicated that some deaths recorded as other causes might instead be caused by cancer or its treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cancer is a substantial cause of mortality among solid organ transplant recipients, with major contributions reported from lung cancer and NHL. Cancer\u2010attributable mortality increases with age and time since transplantation, and therefore cancer deaths will become an increasing burden as recipients live longer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32136","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T21:09:35Z","timestamp":1556658575000},"page":"2647-2655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Cancer\u2010attributable mortality among solid organ transplant recipients in the United States: 1987 through 2014"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6997-4004","authenticated-orcid":false,"given":"Anne\u2010Michelle","family":"Noone","sequence":"first","affiliation":[{"name":"Divison of Cancer Control and Population Sciences National Cancer Institute Bethesda 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