{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:35:59Z","timestamp":1792157759107,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 CA 090381-15"],"award-info":[{"award-number":["P50 CA 090381-15"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 CA 009001"],"award-info":[{"award-number":["T32 CA 009001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000892","name":"Prostate Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,8,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The World Cancer Research Fund classifies as \u201cstrong evidence\u201d the link between obesity and the risk of advanced prostate cancer. In light of the different hormonal profiles associated with where adipose is stored, this study investigated the role of objectively measured body fat distribution and the risk of clinically relevant prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective study of 1832 men in the Age, Gene\/Environment Susceptibility\u2013Reykjavik study. From 2002 to 2006, participants underwent baseline computed tomography imaging of fat deposition, bioelectric impedance analysis, and measurement of body mass index (BMI) and waist circumference. Men were followed through linkage with nationwide cancer registries for the incidence of total (n\u00a0=\u00a0172), high\u2010grade (Gleason grade\u00a0\u22658; n\u00a0=\u00a043), advanced (\u2265cT3b\/N1\/M1 at diagnosis or fatal prostate cancer over follow\u2010up; n\u00a0=\u00a041), and fatal prostate cancer (n\u00a0=\u00a031) through 2015. Cox regression was used to evaluate the association between adiposity measures and prostate cancer outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among all men, visceral fat (hazard ratio [HR], 1.31 per 1\u2013standard deviation [SD] increase; 95% confidence interval [CI], 1.00\u20101.72) and thigh subcutaneous fat (HR, 1.37 per 1\u2010SD increase; 95% CI, 1.00\u20101.88) were associated with risk of advanced and fatal disease, respectively. Among men who were leaner based on BMI, visceral fat was associated with both advanced and fatal disease. BMI and waist circumference were associated with a higher risk of advanced and fatal disease. No adiposity measures were associated with total or high\u2010grade disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Specific fat depots as well as BMI and waist circumference were associated with the risk of aggressive prostate cancer, which may help to elucidate underlying mechanisms and target intervention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32167","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T04:02:54Z","timestamp":1560139374000},"page":"2877-2885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Body fat distribution on computed tomography imaging and prostate cancer risk and mortality in the AGES\u2010Reykjavik study"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2843-687X","authenticated-orcid":false,"given":"Barbra A.","family":"Dickerman","sequence":"first","affiliation":[{"name":"Department of Epidemiology Harvard T. H. Chan School of Public Health Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna E.","family":"Torfadottir","sequence":"additional","affiliation":[{"name":"Centre for Public Health Sciences University of Iceland Reykjavik Iceland"},{"name":"Icelandic Cancer Registry Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unnur A.","family":"Valdimarsdottir","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T. H. Chan School of Public Health Boston Massachusetts"},{"name":"Centre for Public Health Sciences University of Iceland Reykjavik Iceland"},{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Giovannucci","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T. H. Chan School of Public Health Boston Massachusetts"},{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women\u2019s Hospital and Harvard Medical School Boston Massachusetts"},{"name":"Department of Nutrition Harvard T. H. Chan School of Public Health Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T. H. Chan School of Public Health Boston Massachusetts"},{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women\u2019s Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Aspelund","sequence":"additional","affiliation":[{"name":"Centre for Public Health Sciences University of Iceland Reykjavik Iceland"},{"name":"Icelandic Heart Association Kopavogur Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laufey","family":"Tryggvadottir","sequence":"additional","affiliation":[{"name":"Icelandic Cancer Registry Reykjavik Iceland"},{"name":"Faculty of Medicine University of Iceland Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara G.","family":"Sigurdardottir","sequence":"additional","affiliation":[{"name":"Centre for Public Health Sciences University of Iceland Reykjavik Iceland"},{"name":"Faculty of Medicine University of Iceland Reykjavik Iceland"},{"name":"Department of Education and Prevention Icelandic Cancer Society Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara B.","family":"Harris","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Population Sciences Intramural Research Program, National Institute on Aging Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore J.","family":"Launer","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Population Sciences Intramural Research Program, National Institute on Aging Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilmundur","family":"Gudnason","sequence":"additional","affiliation":[{"name":"Icelandic Cancer Registry Reykjavik Iceland"},{"name":"Icelandic Heart Association Kopavogur Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Markt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T. H. Chan School of Public Health Boston Massachusetts"},{"name":"Department of Population and Quantitative Health Sciences Case Western Reserve University Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorelei A.","family":"Mucci","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T. H. Chan School of Public Health Boston Massachusetts"},{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women\u2019s Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0229"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0609"},{"key":"e_1_2_8_4_1","unstructured":"World Cancer Research Fund International\/American Institute for Cancer Research.Continuous Update Project Report: Diet Nutrition Physical Activity and Prostate Cancer.http:\/\/www.wcrf.org\/sites\/default\/files\/Prostate-Cancer-2014-Report.pdf. 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