{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:10:40Z","timestamp":1789513840878,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["VA\/UCLA National Clinician Scholars Program"],"award-info":[{"award-number":["VA\/UCLA National Clinician Scholars Program"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hemiablation is a less morbid treatment alternative for appropriately selected patients with unilateral prostate cancer (PCa). However, to the authors\u2019 knowledge, traditional diagnostic techniques inadequately identify appropriate candidates. In the current study, the authors quantified the accuracy for identifying hemiablation candidates using contemporary diagnostic techniques, including multiparametric magnetic resonance imaging (mpMRI) and MRI\u2010fusion with complete systematic template biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of patients undergoing MRI and MRI\u2010fusion prostate biopsy, including full systematic template biopsy, prior to radical prostatectomy in a single tertiary academic institution between June 2010 and February 2018 was performed. Hemiablation candidates had unilateral intermediate\u2010risk PCa (Gleason score [GS] of 3+4 or 4+3, clinical T classification \u2264T2, and prostate\u2010specific antigen level &lt;20\u00a0ng\/dL) on MRI\u2010fusion biopsy and 2) no contralateral highly or very highly suspicious Prostate Imaging Reporting and Data System version 2 (PI\u2010RADSv2) MRI lesions. Hemiablation candidates were inappropriately selected if pathologists identified contralateral GS \u22653+4 or high\u2010risk ipsilateral PCa on prostatectomy. The authors tested a range of hemiablation inclusion criteria and performed multivariable analysis of preoperative predictors of undetected contralateral disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 665 patients, 92 met primary hemiablation criteria. Of these 92 patients, 44 (48%) were incorrectly identified due to ipsilateral GS \u22653+4 tumors crossing the midline (21 patients), undetected distinct contralateral GS \u22653+4 tumors (20 patients), and\/or ipsilateral high\u2010risk PCa (3 patients) on prostatectomy. The rate of undetected contralateral disease ranged from 41% to 48% depending on inclusion criteria. On multivariable analysis, men with anterior index tumors were found to be 2.4 times more likely to harbor undetected contralateral GS \u22653+4 PCa compared with men with posterior lesions (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinicians and patients must weigh the risk of inadequate oncologic treatment against the functional benefits of hemiablation. Further investigation into methods for improving patient selection for hemiablation is necessary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32170","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T08:54:00Z","timestamp":1556700840000},"page":"2955-2964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Do contemporary imaging and biopsy techniques reliably identify unilateral prostate cancer? Implications for hemiablation patient selection"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0032-047X","authenticated-orcid":false,"given":"David C.","family":"Johnson","sequence":"first","affiliation":[{"name":"National Clinician Scholars Program, Department of Veterans Affairs Los Angeles California"},{"name":"Department of Urology, David Geffen School of Medicine University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason J.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology, David Geffen School of Medicine University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna","family":"Kwan","sequence":"additional","affiliation":[{"name":"Department of Urology, David Geffen School of Medicine University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle E.","family":"Barsa","sequence":"additional","affiliation":[{"name":"Department of Urology, David Geffen School of Medicine University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohrab A.","family":"Mirak","sequence":"additional","affiliation":[{"name":"Department of Radiology, David Geffen School of Medicine University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aydin","family":"Pooli","sequence":"additional","affiliation":[{"name":"Department of Urology, David Geffen School of Medicine University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Sadun","sequence":"additional","affiliation":[{"name":"Department of Urology, David Geffen School of Medicine University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Jayadevan","sequence":"additional","affiliation":[{"name":"Department of Urology, David Geffen School of Medicine University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Urology, David Geffen School of Medicine University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan M.","family":"Priester","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of California at Los 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