{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:22Z","timestamp":1786977502741,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","award":["66737"],"award-info":[{"award-number":["66737"]}],"id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000869","name":"Susan G. Komen for the Cure","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000869","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,9,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Young age is a known factor associated with suboptimal adherence to endocrine therapy (ET) for adjuvant breast cancer (BC) treatment. This study was aimed at assessing nonadherent behaviors and associated factors among young women with early\u2010stage hormone receptor\u2013positive BC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      As part of a multicenter, prospective cohort of women with a diagnosis of BC at or under the age of 40\u00a0years, participants were surveyed 30\u00a0months after their diagnosis about adherent behaviors. Among those who reported taking ET, adherence was measured with a 3\u2010item Likert\u2010type scale: Do you ever forget to take your ET? If you feel worse when you take your ET, do you stop taking it? Did you take your ET exactly as directed by your doctor over the last 3\u00a0months? Women reporting at least 1 nonadherent behavior were classified as nonadherers. Variables with a\n                      <jats:italic>P<\/jats:italic>\n                      value\u00a0&lt;.20 were included in a multivariable logistic model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 384 women, 194 (51%) were classified as nonadherers. Univariate factors that retained significance in the multivariable model included educational level (odds ratio [OR], 0.50 for high vs low;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.04), level of social support according to the Medical Outcome Study Social Support Survey (OR, 0.98 per 1 point;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01), and confidence with the decision regarding ET measured on a 0 to 10 numerical scale (OR, 0.63 for high vs low;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings from this study could help to identify young patients at higher risk for nonadherence. Interventions adapted to the level of education and aimed at reinforcing support and patients' confidence in their decision to take ET could improve adherence and associated outcomes in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32192","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T14:52:45Z","timestamp":1558623165000},"page":"3266-3274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Nonadherent behaviors among young women on adjuvant endocrine therapy for breast cancer"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9376-5966","authenticated-orcid":false,"given":"Johanna","family":"Wassermann","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Boston Massachusetts"},{"name":"Pierre Louis Institute of Epidemiology and Public Health Sorbonne University, French National Institute of Health and Medical Research Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari I.","family":"Gelber","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoshana M.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J.","family":"Ruddy","sequence":"additional","affiliation":[{"name":"Department of Oncology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rulla M.","family":"Tamimi","sequence":"additional","affiliation":[{"name":"Department of Medicine Channing Division of Network Medicine, Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Schapira","sequence":"additional","affiliation":[{"name":"Department of Medicine Stanford Cancer Institute Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia F.","family":"Borges","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine University of Colorado Cancer Center Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Come","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine Beth Israel Deaconess Medical Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan E.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4722-4824","authenticated-orcid":false,"given":"Ann H.","family":"Partridge","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,23]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Breast Cancer Facts & Figures 2015\u20102016","author":"American Cancer 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