{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:33:45Z","timestamp":1791974025121,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Minor salivary gland carcinomas of the head and neck are rare cancers with variable clinical behavior. This study explored the incidence, pathology, clinical behavior, and factors predictive of outcomes in a large cohort of patients treated at Memorial Sloan Kettering Cancer Center over a 30\u2010year period (1985\u20102015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical, pathological, treatment, and outcome data were collected. Unadjusted and adjusted hazard ratios for each variable were calculated with univariate and multivariable Cox regression for survival and recurrence outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred fifty patients were included: 55% were female, 56% were younger than 60\u00a0years, and the median follow\u2010up was 74\u00a0months (range, 1\u2010364\u00a0months). The most common site was the oral cavity with 305 tumors (68%), which was followed by the oropharynx with 96 (21%), the sinonasal cavity with 38 (8%), the trachea with 7 (2%), and the larynx with 4 (1%). The most common histological types were mucoepidermoid carcinoma (180 tumors [40%]), adenoid cystic carcinoma (141 tumors [31%]), and polymorphous low\u2010grade adenocarcinoma (54 tumors [12%]). The 5\u2010year predicted overall survival rate was 86%, and the disease\u2010specific survival rate was 94% at 5\u00a0years. Pathology and tumor stage were significant variables on multivariate analysis for overall survival, disease\u2010specific survival, recurrence\u2010free survival, local recurrence\u2013free survival, regional recurrence\u2013free survival, and distant recurrence\u2013free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>American Joint Committee on Cancer stage and pathology were the most predictive variables across all outcomes. Tumor site, postoperative radiotherapy, and margin status were not statistically significant variables after tumor stage and pathology were controlled for in most outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32208","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T17:15:13Z","timestamp":1559927713000},"page":"3354-3366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Minor salivary gland tumors of the head and neck\u2014Memorial Sloan Kettering experience: Incidence and outcomes by site and histological type"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4666-836X","authenticated-orcid":false,"given":"Ashley J.","family":"Hay","sequence":"first","affiliation":[{"name":"Head and Neck Service, Department of Surgery Memorial Sloan Kettering Cancer Center New York New 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