{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:08:16Z","timestamp":1778630896215,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:00:00Z","timestamp":1561075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011634","name":"Varda and Boaz Dotan Research Center for Hemato-Oncology Research, Tel Aviv University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011634","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Autologous stem cell transplantation (ASCT) is a potential consolidation therapy for acute myeloid leukemia (AML). This study was designed to develop a prediction model for leukemia\u2010free survival (LFS) in a cohort of patients with de novo AML treated with ASCT during their first complete remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a registry study of 956 patients reported to the European Society for Blood and Marrow Transplantation. The primary outcome was LFS. Multivariate Cox regression modeling with backward selection was used to select variables for the construction of the nomogram. The nomogram's performance was evaluated with discrimination (the area under the receiver operating characteristic curve [AUC]) and calibration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age and cytogenetic risk (with or without FMS\u2010like tyrosine kinase 3 internal tandem duplication) were predictive of LFS and were used for the construction of the nomogram. Each factor in the nomogram was ascribed points according to its predictive weight. Through the calculation of the total score, the probability of LFS at 1, 3, and 5\u00a0years for each patient could be estimated. The discrimination of the nomogram, measured as the AUC, was 0.632 (95% confidence interval [CI], 0.595\u20100.669), 0.670 (95% CI, 0.635\u20100.705), and 0.687 (95% CI, 0.650\u20100.724), respectively. Further validation with bootstrapping showed similar AUCs (0.629 [95% CI, 0.597\u20100.657], 0.667 [95% CI, 0.633\u20100.699], and 0.679 [95% CI, 0.647\u20100.712], respectively), and this suggested that the model was not overfitted. Calibration was excellent. Patients were stratified into 4 incremental 5\u2010year prognostic groups, with the probabilities of LFS and overall survival ranging from 25% to 64% and from 33% to 79%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Auto\u2010AML nomogram score is a tool integrating individual prognostic factors to provide a probabilistic estimation of LFS after ASCT for patients with AML.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32344","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T09:26:00Z","timestamp":1561109160000},"page":"3566-3573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Individualized prediction of leukemia\u2010free survival after autologous stem cell transplantation in acute myeloid leukemia"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-8032","authenticated-orcid":false,"given":"Roni","family":"Shouval","sequence":"first","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Division Chaim Sheba Medical Center at Tel HaShomer Ramat\u2010Gan Israel"},{"name":"Sackler School of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Dr. Pinchas Bornstein Talpiot Medical Leadership Program Chaim Sheba Medical Center at Tel HaShomer Ramat\u2010Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cell Therapy Saint\u2010Antoine Hospital Paris France"},{"name":"Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation Saint\u2010Antoine Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0108-5769","authenticated-orcid":false,"given":"Norbert C.","family":"Gorin","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cell Therapy Saint\u2010Antoine Hospital Paris France"},{"name":"Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation Saint\u2010Antoine Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bomze","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Division Chaim Sheba Medical Center at Tel HaShomer Ramat\u2010Gan Israel"},{"name":"Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Houhou","sequence":"additional","affiliation":[{"name":"Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation Saint\u2010Antoine Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Transplantation and Cell Therapy Program Marseille Cancer Research Center, Paoli Calmettes Institute Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsila","family":"Zuckerman","sequence":"additional","affiliation":[{"name":"Department of Hematology Rambam Medical Center Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela M.","family":"Baerlocher","sequence":"additional","affiliation":[{"name":"Department of Hematology, Inselspital Bern University Hospital, University of Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saveria","family":"Capria","sequence":"additional","affiliation":[{"name":"Division of Hematology Sapienza University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Forcade","sequence":"additional","affiliation":[{"name":"Service H\u00e9matologie Clinique et Th\u00e9rapie Cellulaire Centre Hospitalier Universitaire de Bordeaux H\u00f4pital Haut\u2010Leveque Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Huynh","sequence":"additional","affiliation":[{"name":"Department of Hematology Institut Universitaire du Cancer Toulouse Oncopole Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Saccardi","sequence":"additional","affiliation":[{"name":"Department of Cellular Therapies and Transfusion Medicine Careggi University Hospital Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Martino","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant Unit, Hemato\u2010Oncology Department Grande Ospedale Metropolitano 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