{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:59:01Z","timestamp":1773269941934,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009326","name":"Cancer Research Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000015","name":"Canadian Cancer Society Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000163","name":"Pediatric Oncology Group of Ontario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000163","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013683","name":"C17 Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013683","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Treatments against ALL might lead to later cognitive effects and alterations in brain structure in survivors but to the authors' knowledge the observed variability in the severity of neurocognitive deficits is not fully understood. The objective of the current study was to investigate abnormalities in visual short\u2010term memory (VSTM) brain activation in survivors of childhood ALL using magnetoencephalography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A VSTM task was completed by 40 survivors of ALL and 26 controls. VSTM capacity (Cowan K) and brain activation were assessed during the retention period of the task (400\u20101400\u00a0milliseconds) using a standard minimum norm source localization method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Performance (Cowan K) was found to be similar between survivors of ALL and controls. Atypical brain activation was found in survivors of ALL during the task, including overactivation of regions usually involved in VSTM (lateral occipital, precentral gyrus, and postcentral gyrus), recruitment of regions that typically are not involved in VSTM (superior\/middle temporal gyrus and supramarginal gyrus), and lower activation of frontal brain regions (inferior frontal gyrus). These patterns of activation were modulated by the age at the time of cancer onset (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01) because activity was found to be reduced in participants who were younger at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of the current study suggest a pattern of neural inefficiency and compensatory activity during VSTM in survivors of ALL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32374","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T09:43:11Z","timestamp":1563270191000},"page":"3639-3648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Visual short\u2010term memory activation patterns in adult survivors of childhood acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-0663","authenticated-orcid":false,"given":"Aubree","family":"Boulet\u2010Craig","sequence":"first","affiliation":[{"name":"CHU Sainte\u2010Justine Research Center Montreal Quebec Canada"},{"name":"Department of Psychology University of Montreal Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Robaey","sequence":"additional","affiliation":[{"name":"CHU Sainte\u2010Justine Research Center Montreal Quebec Canada"},{"name":"Department of Psychology University of Montreal Montreal Quebec Canada"},{"name":"Department of Psychiatry University of Montreal Montreal Quebec Canada"},{"name":"Department of Psychiatry University of Ottawa Ottawa Ontario Canada"},{"name":"Children's Hospital of Eastern Ontario Ottawa Ontario 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