{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:49:30Z","timestamp":1760316570186,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["6256-13"],"award-info":[{"award-number":["6256-13"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01 CA213140"],"award-info":[{"award-number":["U01 CA213140"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,11,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Late mortality was investigated in patients with chronic myelogenous leukemia (CML) who underwent blood or bone marrow transplant (BMT) with or without prior tyrosine kinase inhibitor (TKI) therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>By using data from the Blood or Marrow Transplant Survivor Study, the authors examined late mortality in 447 patients with CML who underwent BMT between 1974 and 2010, conditional on surviving \u22652\u00a0years post\u2010BMT. For vital status information, the medical records, the National Death Index, and the Accurint database were used. Standardized mortality ratios (SMRs) were calculated using general population age\u2010specific, sex\u2010specific, and calendar\u2010specific mortality rates. Kaplan\u2010Meier techniques and Cox regression were used for all\u2010cause mortality analyses. Cumulative incidence and proportional subdistribution hazards models for competing risks were used for cause\u2010specific mortality analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 10\u2010year overall survival rate was 65.7% and 73% for those who underwent transplant with and without pre\u2010BMT exposure to TKI therapy, respectively. Patients who underwent transplant with and without pre\u2010BMT TKI experienced SMRs of 6.4 and 6.4, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.8); and the SMRs were 11.6 and 8.1, respectively, for those with high\u2010risk disease (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.2). Independent predictors of non\u2013CML\u2010related mortality included chronic graft\u2010versus\u2010host disease (hazard ratio [HR], 2.8; 95% CI, 1.8\u20104.4) and busulfan\/cyclophosphamide conditioning (HR, 0.5; 95% CI, 0.3\u20100.9; reference, total body irradiation\/cyclophosphamide conditioning). The 20\u2010year cumulative incidence of CML\u2010related and non\u2013CML\u2010related mortality was 6% and 36%, respectively, for the entire cohort. Both CML\u2010related mortality (HR, 1.0; 95% CI, 0.1\u201012.6) and non\u2013CML\u2010related mortality (HR, 1.3; 95% CI, 0.6\u20103.1) were comparable for those with and without pre\u2010BMT TKI therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The similar late mortality experienced by patients with CML who undergo transplantation with or without pre\u2010BMT TKIs suggests that allogeneic BMT can be considered in the context of TKI intolerance or nonadherence. The prevention of post\u2010BMT non\u2013CML\u2010related mortality could favorably affect long\u2010term survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32443","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T15:13:43Z","timestamp":1565795623000},"page":"4033-4042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Late mortality after bone marrow transplant for chronic myelogenous leukemia in the context of prior tyrosine kinase inhibitor exposure: A Blood or Marrow Transplant Survivor Study (BMTSS) report"],"prefix":"10.1002","volume":"125","author":[{"given":"Jessica","family":"Wu","sequence":"first","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey","family":"Hageman","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liton","family":"Francisco","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily C.","family":"Ness","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariel","family":"Parman","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Kung","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Watson","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Weisdorf","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Hematology\/Hematopoietic Cell Transplantation City of Hope National Medical Center Duarte California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip B.","family":"McGlave","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Forman","sequence":"additional","affiliation":[{"name":"Department of Medicine City of Hope National Medical Center Duarte California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukta","family":"Arora","sequence":"additional","affiliation":[{"name":"Hematology\u2010Oncology and Blood and Marrow Transplantation University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2604-8603","authenticated-orcid":false,"given":"Saro H.","family":"Armenian","sequence":"additional","affiliation":[{"name":"Department of Social Sciences and Pediatrics City of Hope National Medical Center Duarte 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