{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:18:20Z","timestamp":1783131500836,"version":"3.54.6"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There is a controversy about late\u2010onset congestive heart failure (CHF) among breast cancer survivors. This study investigated the incidence rate and risk factors of late\u2010onset CHF more than 2\u00a0years after the breast cancer diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nationwide, retrospective study was conducted with the National Health Information Database. With 1:3 age\u2010 and sex\u2010matched noncancer controls, Cox proportional hazard regression models were used to analyze the incidence and risk factors of late CHF. The cumulative incidence rate of late CHF was evaluated with a Kaplan\u2010Meier analysis and a log\u2010rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 91,227 cases (286,480 person\u2010years) and 273,681 controls (884,349 person\u2010years) were evaluated between January 2007 and December 2013. The risks of late CHF were higher in cases than controls (hazard ratio [HR], 1.396; 95% confidence interval [CI], 1.268\u20101.538). Younger survivors (age\u00a0\u2264\u00a050\u00a0years) showed a higher risk of late CHF than their younger counterparts (HR, 2.903; 95% CI, 2.425\u20103.474). Although older age was a risk factor for late CHF, older survivors (age\u00a0\u2265\u00a066\u00a0years) showed no difference in the risk of late CHF in comparison with their counterparts (HR, 0.906; 95% CI, 0.757\u20101.084). Anthracyclines and taxanes were risk factors for late CHF, although trastuzumab, radiation, and endocrine therapy were not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Young breast cancer survivors have a greater risk of late CHF than the young population without cancer. More attention should be paid to young breast cancer survivors who receive taxane\u2010 or anthracycline\u2010based regimens over the long term.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32485","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T16:23:51Z","timestamp":1566923031000},"page":"181-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Long\u2010term risk of congestive heart failure in younger breast cancer survivors: A nationwide study by the SMARTSHIP group"],"prefix":"10.1002","volume":"126","author":[{"given":"Jihyoun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery Soonchunhyang University Seoul Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho","family":"Hur","sequence":"additional","affiliation":[{"name":"Department of Surgery National Health Insurance Service Ilsan Hospital Goyang\u2010Si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jo","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Surgery Chonbuk National University Hospital Jeonju\u2010Si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungdo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Medicine Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Soonchunhyang University Seoul Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So\u2010Youn","family":"Jung","sequence":"additional","affiliation":[{"name":"Breast Cancer Center National Cancer Center Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zisun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Soonchunhyang University College of Medicine Bucheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ku Sang","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Breast\u2010Thyroid Surgery Dongkang Medical Center Ulsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hyuk","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Soonchunhyang University Seoul Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u2010Hwan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Surgery Ajou University, School of Medicine Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hoo","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Surgery Chonbuk National University Hospital Jeonju\u2010Si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-8530","authenticated-orcid":false,"given":"Il Yong","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Surgery, Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"National Comprehensive Cancer Network.NCCN guidelines for survivorship. Accessed April 24 2018.https:\/\/www.nccn.org\/professionals\/physician_gls\/default.aspx."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.5400"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30535-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013777"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv301"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.5841"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.48.7884"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.4976"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs317"},{"key":"e_1_2_8_11_1","unstructured":"National Health Insurance Sharing Service. Accessed April 24 2018.https:\/\/nhiss.nhis.or.kr\/bd\/ab\/bdaba000eng.do;jsessionid=j2AapQ2ykFXHAEH6j3VuSGMEa2tX67Bo4dKm2I6z76BWQ2lVMFOp11PZs8ka5iE1.primrose22_servlet_engine1."},{"key":"e_1_2_8_12_1","first-page":"799","article-title":"Data resource profile: the National Health Information Database of the National Health Insurance Service in South Korea","volume":"46","author":"Seong SC","year":"2017","journal-title":"Int J Epidemiol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2016.31.2.292"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx585"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2018.33.e276"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210471"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13051"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy026"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28385"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951115000906"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000376"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e3283529060"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12589"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e31825a8c22"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.32485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.32485","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.32485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T15:55:46Z","timestamp":1760284546000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.32485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,27]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/cncr.32485"],"URL":"https:\/\/doi.org\/10.1002\/cncr.32485","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,27]]},"assertion":[{"value":"2019-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}