{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:02:35Z","timestamp":1783393355082,"version":"3.54.6"},"reference-count":18,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA078938"],"award-info":[{"award-number":["R01 CA078938"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["R6502\u201016"],"award-info":[{"award-number":["R6502\u201016"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,12,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with non\u2010Hodgkin lymphoma (NHL) have an increased risk of venous thromboembolism (VTE), particularly when they are receiving treatment. Blood or marrow transplantation (BMT) is recommended for relapsed\/refractory NHL, and the risk of VTE after these patients undergo BMT is uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with NHL who survived 2\u00a0years or longer after BMT were surveyed for long\u2010term health outcomes, including VTE. The median follow\u2010up was 8.1\u00a0years (interquartile range, 5.6\u201012.9\u00a0years). The risk of VTE in 734 patients with NHL versus 897 siblings without a history of cancer and the risk factors associated with VTE were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BMT survivors of NHL were at increased risk for VTE in comparison with siblings (odds ratio for allogeneic BMT survivors, 4.61; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001; odds ratio for autologous BMT survivors, 1.75; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.035). The cumulative incidence of VTE was 6.3%\u00a0\u00b1\u00a00.9% at 5\u00a0years after BMT and 8.1%\u00a0\u00b1\u00a01.1% at 10\u00a0years after BMT. In allogeneic BMT recipients, an increased body mass index (BMI; hazard ratio [HR] for BMI of 25\u201030\u00a0kg\/m<jats:sup>2<\/jats:sup>, 3.52; 95% confidence interval [CI], 1.43\u20108.64; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006; HR for BMI\u00a0&gt;\u00a030\u00a0kg\/m<jats:sup>2<\/jats:sup>, 3.44; 95% CI, 1.15\u201010.23; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.027) and a history of chronic graft\u2010versus\u2010host disease (HR, 3.33; 95% CI, 1.59\u20106.97; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) were associated with an increased risk of VTE. Among autologous BMT recipients, a diagnosis of coronary artery disease (HR, 5.94; 95% CI, 1.7\u201020.71; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005) and prior treatment with carmustine (HR, 4.91; 95% CI, 1.66\u201014.51; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004) were associated with increased VTE risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with NHL who survive BMT are at risk for developing late occurring VTE, and ongoing vigilance for this complication is required. Future studies assessing the role of thromboprophylaxis in high\u2010risk patients with NHL are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32488","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T09:25:33Z","timestamp":1567157133000},"page":"4498-4508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Risk of venous thromboembolism in patients with non\u2010Hodgkin lymphoma surviving blood or marrow transplantation"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5542-4754","authenticated-orcid":false,"given":"Radhika","family":"Gangaraju","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Hageman","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Wu","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liton","family":"Francisco","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Kung","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Ness","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariel","family":"Parman","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Weisdorf","sequence":"additional","affiliation":[{"name":"University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Forman","sequence":"additional","affiliation":[{"name":"City of Hope Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukta","family":"Arora","sequence":"additional","affiliation":[{"name":"University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2604-8603","authenticated-orcid":false,"given":"Saro H.","family":"Armenian","sequence":"additional","affiliation":[{"name":"City of Hope Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7755-5683","authenticated-orcid":false,"given":"Smita","family":"Bhatia","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602504"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1185782"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11623"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.05.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.05.021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-258624"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.164012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702419"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and 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