{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:12:19Z","timestamp":1791825139510,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["50543\u20102018"],"award-info":[{"award-number":["50543\u20102018"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","award":["20190003"],"award-info":[{"award-number":["20190003"]}],"id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,1,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although several prospective studies have reported the efficacy of stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC), treatment\u2010related toxicity varies and has not been determined. Therefore, the authors evaluated the safety and efficacy of SBRT for patients with HCC in a hepatitis B virus\u2010endemic area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter phase 2 trial enrolled patients with unresectable HCC. Patients received SBRT with 45 to 60 Gy in 3 fractions. To evaluate gastroduodenal toxicity, esophagogastroduodenoscopy (EGD) was performed before and 2\u00a0months after SBRT. The primary endpoint was treatment\u2010related severe toxicity at 1\u00a0year after SBRT. The secondary endpoints were the 2\u2010year local control, progression\u2010free survival, and overall survival rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 74 patients were enrolled between January 2012 and April 2015, and 65 eligible patients were analyzed. One patient experienced radiation\u2010induced liver disease with acute grade \u22653 toxicity 1\u00a0month after SBRT. In addition, 1 patient had a grade 3 esophageal ulcer with stenosis 5\u00a0months after SBRT. The actuarial rate of treatment\u2010related severe toxicity at 1\u00a0year was 3%. The pre\u2010SBRT and post\u2010SBRT EGD findings were not significantly different among the 57 evaluable patients who underwent EGD. The 2\u2010year and 3\u2010year local control rates were 97% and 95%, respectively. The progression\u2010free and overall survival rates were 48% and 84% at 2\u00a0years, respectively, and 36% and 76% at 3\u00a0years, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>With a median follow\u2010up of 41\u00a0months, this prospective multicenter study demonstrated that SBRT for patients with HCC is well tolerated and is an effective treatment modality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32502","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T13:59:30Z","timestamp":1574258370000},"page":"363-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["A phase 2 multicenter study of stereotactic body radiotherapy for hepatocellular carcinoma: Safety and efficacy"],"prefix":"10.1002","volume":"126","author":[{"given":"Won Il","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Korea Institute of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Hyun","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Soonchunhyang University College of Medicine Bucheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7459-6316","authenticated-orcid":false,"given":"Mi\u2010Sook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Korea Institute of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Ju","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea Institute of Radiological and Medical Sciences 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