{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:59:07Z","timestamp":1786798747225,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA076292"],"award-info":[{"award-number":["P30 CA076292"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21 CA191594"],"award-info":[{"award-number":["R21 CA191594"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R25 CA191314"],"award-info":[{"award-number":["R25 CA191314"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Fatigue is a common and disabling side effect of targeted therapies such as tyrosine kinase inhibitors (TKIs) used to treat chronic myeloid\u00a0leukemia (CML). The goal of the current study was to conduct a pilot randomized trial of the first cognitive behavioral intervention developed for fatigue due to targeted therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with CML treated with a TKI who were reporting moderate to severe fatigue were recruited and randomized 2:1 to cognitive behavioral therapy for targeted therapy\u2013related fatigue (CBT\u2010TTF) delivered via FaceTime for the iPad or to a waitlist control (WLC) group. The outcomes were acceptability, feasibility, and preliminary efficacy for fatigue (Functional Assessment of Chronic Illness Therapy\u2013Fatigue; primary outcome) and quality of life (Functional Assessment of Cancer Therapy\u2013General; secondary outcome). Participants were assessed before randomization and after treatment (ie, approximately 18\u00a0weeks later).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 44 patients (mean age, 55\u00a0years; 48% female) were assigned to CBT\u2010TTF (n\u00a0=\u00a029) or WLC (n\u00a0=\u00a015). The study participation rate was 59%. Among the patients assigned to CBT\u2010TTF, 79% completed the intervention. Intent\u2010to\u2010treat analyses indicated that patients assigned to CBT\u2010TTF demonstrated greater improvements in fatigue (<jats:italic>d<\/jats:italic>\u00a0=\u00a01.06; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and overall quality of life (<jats:italic>d<\/jats:italic>\u00a0=\u00a01.15; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005) than those assigned to WLC. More patients randomized to CBT\u2010TTF than WLC demonstrated clinically significant improvements in fatigue (85% vs 29%) and quality of life (88% vs 54%; <jats:italic>P<\/jats:italic> values\u00a0\u2264\u00a0.016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CBT\u2010TTF displays preliminary efficacy in improving fatigue and quality of life among fatigued patients with CML treated with TKIs. The findings suggest that a larger randomized study is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32521","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T18:16:18Z","timestamp":1569435378000},"page":"174-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Internet\u2010assisted cognitive behavioral intervention for targeted therapy\u2013related fatigue in chronic myeloid leukemia: Results from a pilot randomized trial"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7353-3711","authenticated-orcid":false,"given":"Heather S. L.","family":"Jim","sequence":"first","affiliation":[{"name":"Department of Health Outcomes and Behavior Moffitt Cancer Center Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-5306","authenticated-orcid":false,"given":"Kelly A.","family":"Hyland","sequence":"additional","affiliation":[{"name":"Department of Psychology University of South Florida Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley M.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Psychology University of South Florida Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Pinilla\u2010Ibarz","sequence":"additional","affiliation":[{"name":"Department of Malignant Hematology Moffitt Cancer Center Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendra","family":"Sweet","sequence":"additional","affiliation":[{"name":"Department of Malignant Hematology Moffitt Cancer Center Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"Gielissen","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology Amsterdam University Medical Centers, University of Amsterdam Amsterdam the Netherlands"},{"name":"Academy Het Dorp Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-0303","authenticated-orcid":false,"given":"Hailey","family":"Bulls","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Behavior Moffitt Cancer Center Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8691-8132","authenticated-orcid":false,"given":"Aasha I.","family":"Hoogland","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Behavior Moffitt Cancer Center Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul B.","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Healthcare Delivery Research Program National Cancer Institute Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Knoop","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology Amsterdam University Medical Centers, University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-358135"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-347575"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1630-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-477687"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.51"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30815"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.8270"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.4495"},{"key":"e_1_2_8_10_1","unstructured":"Network National Comprehensive Cancer. 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