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This study assessed trends in <jats:italic>BRCA<\/jats:italic> testing in women younger than 40\u00a0years without diagnosed breast or ovarian cancer (unaffected young women [UYW]) for cancer prevention between 2006 and 2017 in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 93,278 adult women 18 to 65\u00a0years old with insurance claims for <jats:italic>BRCA<\/jats:italic> testing between 2006 and 2017 from the de\u2010identified Optum Clinformatics Data Mart database. The data contained medical claims and administrative information from privately insured individuals in the United States. The proportion of <jats:italic>BRCA<\/jats:italic> testing in UYW younger than 40\u00a0years among adult women aged 18 to 65\u00a0years who received <jats:italic>BRCA<\/jats:italic> testing was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 2006, only 10.5% of the tests were performed in UYW. The proportion of <jats:italic>BRCA<\/jats:italic> tests performed in UYW increased significantly to 25.5% in 2017 (annual percentage change for the 2006\u20102017 period, 6.9; 95% confidence interval, 6.4\u20107.3; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The increased trend in the proportion of <jats:italic>BRCA<\/jats:italic> tests in UYW significantly differed by region of residence and family history of breast or ovarian cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Over the past decade, there was increased use of <jats:italic>BRCA<\/jats:italic> testing for cancer prevention. Additional efforts are needed to maximize the early detection of women with <jats:italic>BRCA<\/jats:italic> pathogenic variants so that these cancers may be prevented.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32536","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T01:17:53Z","timestamp":1569892673000},"page":"337-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<i>BRCA<\/i> testing in unaffected young women in the United States, 2006\u20102017"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3729-2724","authenticated-orcid":false,"given":"Fangjian","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of Texas Medical Branch at Galveston Galveston Texas"},{"name":"Center for Interdisciplinary Research in Women\u2019s Health The University of Texas Medical Branch at Galveston Galveston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Scholl","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Texas Medical Branch at Galveston Galveston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5243-8464","authenticated-orcid":false,"given":"Erika L.","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of Texas Medical Branch at Galveston Galveston Texas"},{"name":"Center for Interdisciplinary Research in Women\u2019s Health The University of Texas Medical Branch at Galveston Galveston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5007-1080","authenticated-orcid":false,"given":"Abbey B.","family":"Berenson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of Texas Medical Branch at Galveston Galveston Texas"},{"name":"Center for Interdisciplinary Research in Women\u2019s Health The University of Texas Medical Branch at Galveston Galveston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-0927","authenticated-orcid":false,"given":"Yong\u2010Fang","family":"Kuo","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Research in Women\u2019s Health The University of Texas Medical Branch at Galveston Galveston Texas"},{"name":"Office of Biostatistics Department of Preventive Medicine and Community Health The University of Texas Medical Branch at Galveston Galveston Texas"},{"name":"Institute for Translational Science The University of Texas Medical Branch at Galveston Galveston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20128"},{"key":"e_1_2_8_3_1","volume-title":"Breast Cancer Facts & Figures 2015\u20102016","author":"American Cancer Society","year":"2015"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.1066"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/375033"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt095"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-1684"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-5-200509060-00012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199601183340302"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1407"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343790"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2257-y"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju420"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.22.2527"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.12483"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182091ba4"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2017.01.027"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.7112"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp071286"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.166"},{"key":"e_1_2_8_21_1","unstructured":"National Comprehensive Cancer Network.NCCN Clinical Practice Guidelines in Oncology: Genetic\/Familial High\u2010Risk Assessment: Breast and Ovarian. 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