{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:44Z","timestamp":1786977524288,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["DOC 16\u2010009"],"award-info":[{"award-number":["DOC 16\u2010009"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Significant progress was recently observed in the treatment of metastatic melanoma (MM). With &gt;50% of patients now reaching a second line of treatment and a significant improvement in the survival rate, an assessment of quality of life (QoL) during the whole course of the disease becomes necessary. The objective of this study was to describe the QoL of patients with MM in France, from their diagnosis of advanced disease to their death, in real life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>QoL data were collected through MelBase, a prospective, French, multicentric cohort dedicated to the follow\u2010up of adults with MM. QoL was assessed using the EuroQoL\u20105D questionnaire and the Functional Assessment of Cancer Treatment (FACT)\u2010Melanoma questionnaire at the time of study inclusion, every 3\u00a0months, and at the time of each treatment change until death. To assess longitudinal changes from baseline to death, mixed\u2010effect models for repeated\u2010measures analyses were used to control for baseline covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>QoL was assessed in 1435 patients who were included in the study between 2013 and 2018. The median follow\u2010up was 9.4\u00a0months, and 47% of patients died during follow\u2010up. During first\u2010line treatment, the model\u2010based, mean utility score was 0.830 (95% CI, 0.818\u20100.843), the mean FACT\u2010General score was 77.22 (95% CI, 76.23\u201078.22), and the mean FACT\u2010Melanoma score was 129.46 (95% CI, 128.02\u2010130.90). At the time of a change in treatment line, there was a decrease of \u22120.027 (95% CI, \u22120.03, \u22120.02) in the utility score, \u22121.82 (95% CI, \u22121.88, \u22121.76) in the FACT\u2010General score, and \u22122.98 (95% CI, \u22123.05, \u22122.91) in the FACT\u2010Melanoma score compared with first\u2010line treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the MelBase cohort, the QoL among patients with MM seems to be fairly stable over the whole disease course, although a small but significant decrease at time therapy is changed is observed.<\/jats:p>\n                  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