{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:22Z","timestamp":1786977502396,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T00:00:00Z","timestamp":1571356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA016672"],"award-info":[{"award-number":["P30 CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,1,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A single\u2010arm, phase 2 trial demonstrated the efficacy and safety of blinatumomab, a bispecific T\u2010cell\u2013engaging antibody construct, in patients with relapsed\/refractory (r\/r) Philadelphia chromosome\u2013positive (Ph+) acute lymphoblastic leukemia (ALL), a rare hematologic malignancy with limited treatment options. This study compared outcomes with blinatumomab with those of a historical control treated with the standard of care (SOC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The blinatumomab trial enrolled adult patients with Ph+ ALL who were r\/r to at least 1 second\u2010generation tyrosine kinase inhibitor (n\u00a0=\u00a045). Propensity score analysis (PSA) was used to compare outcomes with blinatumomab with those of an external cohort of similar patients receiving SOC chemotherapy (n\u00a0=\u00a055). The PSA mitigated confounding variables between studies by adjusting for imbalances in the age at diagnosis and start of treatment, sex, duration from diagnosis to most recent treatment, prior allogeneic hematopoietic stem cell transplantation, prior salvage therapy, and number of salvage therapies. Bayesian data augmentation was applied to improve power to 80% with data from a phase 3 blinatumomab study in r\/r Philadelphia chromosome\u2013negative ALL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the PSA, the rate of complete remission or complete remission with partial hematologic recovery was 36% for blinatumomab and 25% for SOC, and this resulted in an odds ratio of 1.54 (95% confidence interval [CI], 0.61\u20103.89) or 1.70 (95% credible interval [CrI], 0.94\u20102.94) with Bayesian data augmentation. Overall survival favored blinatumomab over SOC, with a hazard ratio of 0.81 (95% CI, 0.57\u20101.14) or 0.77 (95% CrI, 0.61\u20100.96) with Bayesian data augmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results further support blinatumomab as a treatment option for patients with r\/r Ph+ ALL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32558","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T10:13:59Z","timestamp":1571393639000},"page":"304-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Blinatumomab compared with standard of care for the treatment of adult patients with relapsed\/refractory Philadelphia chromosome\u2013positive B\u2010precursor acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3739-7502","authenticated-orcid":false,"given":"Alessandro","family":"Rambaldi","sequence":"first","affiliation":[{"name":"Department of Oncology and Hematology University of Milan Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1042-6024","authenticated-orcid":false,"given":"Josep\u2010Maria","family":"Ribera","sequence":"additional","affiliation":[{"name":"Clinical Hematology Service Catalan Institute of Oncology, University Hospital Germans Trias i Pujol Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-3307","authenticated-orcid":false,"given":"Hagop M.","family":"Kantarjian","sequence":"additional","affiliation":[{"name":"Department of Leukemia University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Dombret","sequence":"additional","affiliation":[{"name":"Department of Hematology Hopital Saint\u2010Louis, Paris Diderot University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver G.","family":"Ottmann","sequence":"additional","affiliation":[{"name":"Division of Cancer and Genetics, School of Medicine Cardiff University Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony S.","family":"Stein","sequence":"additional","affiliation":[{"name":"Gehr Family Center for Leukemia Research, City of Hope Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Tuglus","sequence":"additional","affiliation":[{"name":"Amgen, Inc Thousand Oaks California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Amgen, Inc Thousand Oaks California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Kim","sequence":"additional","affiliation":[{"name":"Amgen, Inc Thousand Oaks California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Scientific Institute of Romagna for the Study and Treatment of Cancer Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.116954"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw025"},{"key":"e_1_2_8_4_1","unstructured":"National Comprehensive Cancer Network.NCCN Clinical Practice Guidelines in Oncology: Acute Lymphoblastic Leukemia Version I.2018. 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