{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T08:05:44Z","timestamp":1766390744092,"version":"build-2065373602"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In adult patients with acute myeloid leukemia (AML), a matched sibling donor (MSD) is considered the first choice for an allogeneic transplantation. However, a female donor for a male recipient is a poor prognostic factor. The authors compared haploidentical (HAPLO) donors with female MSDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 834 men underwent allogenic transplantation from a female MSD, and 232 men underwent allogenic transplantation from a HAPLO donor. Of these, 86% of HAPLO recipients and 3% of MSD recipients received graft\u2010versus\u2010host disease (GVHD) prophylaxis posttransplantation with high\u2010dose cyclophosphamide. A significant qualitative interaction was observed between donor type and cytogenetics, Therefore, the analyses were stratified on cytogenetics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the men with intermediate\u2010risk AML, 638 received transplantation from a female MSD, and 160 received transplantation from a HAPLO donor. In multivariate analysis, poor risk factors were a HAPLO donor versus an MSD for nonrelapse mortality (hazard ratio [HR], 1.7; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) and patient age for nonrelapse mortality and overall survival (HR, 1.22 [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02] and 1.15 [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02], respectively). HAPLO transplantation resulted in less chronic GVHD (HR, 0.43; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a010<jats:sup>\u22124<\/jats:sup>) but lower leukemia\u2010free survival (HR, 1.7; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). The GVHD\/relapse\u2010free survival (GRFS) was not different. Of the men with high\u2010risk AML, 196 received transplantation from a female MSD, and 72 received transplantation from a HAPLO donor. By multivariate analysis, HAPLO recipients had a lower incidence of relapse (HR, 0.40; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004), better leukemia\u2010free survival (HR, 0.46; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003), better overall survival (HR, 0.43; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003), and better GRFS (HR, 0.54; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In men who have intermediate\u2010risk AML, allogenic transplantation from a sister MSD or a HAPLO donor produces similar GRFS. However, in men who have high\u2010risk AML, a HAPLO donor combined with prophylactic high\u2010dose cyclophosphamide posttransplantation may be a better choice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32629","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T10:45:27Z","timestamp":1574851527000},"page":"1004-1015","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Stem cell transplantation from a haploidentical donor versus a genoidentical sister for adult male patients with acute myelogenous leukemia in first remission: A retrospective study from the acute leukemia working party of the European Society for Blood and Marrow Transplantation"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0108-5769","authenticated-orcid":false,"given":"Norbert\u2010Claude","family":"Gorin","sequence":"first","affiliation":[{"name":"Department of Hematology 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Marseille University, Centre National de la Recherche scientifique, INSERM, CRCM Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"de Groot","sequence":"additional","affiliation":[{"name":"Department of Hematology University of Groningen Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Soci\u00e9","sequence":"additional","affiliation":[{"name":"Department of Hematology and Stem Cell Transplantation Saint Louis Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Henri","family":"Bourhis","sequence":"additional","affiliation":[{"name":"Department of Hematology and Stem Cell Transplantation Gustave Roussy Institute Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Ciceri","sequence":"additional","affiliation":[{"name":"Department of Hematology and Stem Cell Transplantation San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Polge","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cell Therapy Saint\u2010Antoine Hospital Paris France"},{"name":"Institut national de la sant\u00e9 et de la recherche m\u00e9dicale (INSERM) Unit 938, Assistance Publique\u2010Hopitaux de Paris APHP, Sorbonne University Paris France"},{"name":"European Society for Blood and Marrow Transplantation Paris Office Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnon","family":"Nagler","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Chaim Sheba Medical Center Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Mohty","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cell Therapy Saint\u2010Antoine Hospital Paris France"},{"name":"Institut national de la 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