{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:13:23Z","timestamp":1760267603685,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006259","name":"Teva Pharmaceutical Industries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001219","name":"Lymphoma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,3,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Both gemcitabine and bendamustine have been evaluated in patients with recurrent\/refractory Hodgkin lymphoma but to the authors' knowledge not as a doublet. The authors completed a phase 1\/2 trial to identify the optimal dose and frequency of administration and to assess the efficacy of this combination in patients with recurrent\/refractory Hodgkin lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were treated up to a maximum dose of gemcitabine (1000\u00a0mg\/m<jats:sup>2<\/jats:sup> on day 1) and bendamustine (120\u00a0mg\/m<jats:sup>2<\/jats:sup> on days 1 and 2), which was determined to be the recommended phase 2 dose, administered every 21\u00a0days for up to 6 cycles. Patients could discontinue study therapy after 2 cycles to proceed with autologous or allogeneic stem cell transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No dose\u2010limiting toxicities were identified, but 4 patients experienced grade 3 to 5 pulmonary adverse events (toxicity was graded according to Common Terminology Criteria for Adverse Events [version 4]). A total of 26 patients were enrolled having completed a median of 4 prior lines of therapy (range, 1\u20107 lines), including 13 patients at the recommended phase 2 dose, in whom the overall response rate was 69% and the complete response rate was 46%. The median progression\u2010free survival for the phase 2 patients was 11\u00a0months (95% CI, 3\u00a0months to not reached), and the median overall survival for this group had not been reached at the time of last follow\u2010up (95% CI, 4\u00a0months to not reached).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This doublet was found to be tolerable and effective, but patients must be monitored closely for pulmonary toxicity. The authors currently are evaluating this doublet in combination with nivolumab.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32640","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T11:03:50Z","timestamp":1575975830000},"page":"1235-1242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Gemcitabine and bendamustine is a safe and effective salvage regimen for patients with recurrent\/refractory Hodgkin lymphoma: Results of a phase 1\/2 study"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2723-6481","authenticated-orcid":false,"given":"Jonathon B.","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Hematology and Medical Oncology Winship Cancer Institute Emory University Atlanta 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