{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:36:01Z","timestamp":1792805761955,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The focus on noncancer causes of death in patients with breast cancer (BC) remains superficial. The objective of the current study was to assess and quantify causes of death after BC diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 754,270 women with BC in the United States who were diagnosed during 2000 through 2015 and retrieved from the Surveillance, Epidemiology, and End Results (SEER) program were studied. Standardized mortality ratios (SMRs) for causes of death were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the included patients, 183,002 (24.3%) died during the follow\u2010up period. The greatest proportion of deaths (46.2%) occurred within 1 to 5\u00a0years after diagnosis. Most deaths occurred from BC itself or from other cancers, and the number of BC deaths decreased as more years passed after diagnosis. The most common noncancer causes of death within &lt;10\u00a0years after diagnosis were heart diseases followed by cerebrovascular diseases. However, &gt;10\u00a0years after diagnosis, the most common noncancer causes of death were heart diseases followed by Alzheimer disease. Patients had a statistically significant higher risk of death from chronic liver diseases within 5 to 10\u00a0years after diagnosis compared with the general population (SMR, 1.23; 95% CI, 1.09\u20101.38) and had statistically significant higher risks of death from Alzheimer disease (SMR, 1.21; 95% CI, 1.14\u20101.29) and from diseases of the heart (SMR, 1.06; 95% CI, 1.02\u20101.09) &gt;10\u00a0years after diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although BC remains the most common cause of death after BC diagnosis, other non\u2010BC causes of death (mainly heart and cerebrovascular diseases) represent a significant number of deaths among patients with BC. These findings provide important insight into how BC survivors should be counselled regarding future health risks.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32648","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T03:03:18Z","timestamp":1576465398000},"page":"1559-1567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":182,"title":["Causes of death after breast cancer diagnosis: A US population\u2010based analysis"],"prefix":"10.1002","volume":"126","author":[{"given":"Ahmed M.","family":"Afifi","sequence":"first","affiliation":[{"name":"Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-0131","authenticated-orcid":false,"given":"Anas M.","family":"Saad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Ain Shams University Cairo Egypt"},{"name":"Heart and Vascular Institute Cleveland Clinic Foundation Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8230-0343","authenticated-orcid":false,"given":"Muneer J.","family":"Al\u2010Husseini","sequence":"additional","affiliation":[{"name":"Department of Medicine Ascension St John Hospital Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Osama","family":"Elmehrath","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald W.","family":"Northfelt","sequence":"additional","affiliation":[{"name":"Mayo Clinic Cancer Center, Division of Hematology\/Oncology Mayo Clinic Arizona Phoenix Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6931-242X","authenticated-orcid":false,"given":"Mohamad Bassam","family":"Sonbol","sequence":"additional","affiliation":[{"name":"Mayo Clinic Cancer Center, Division of Hematology\/Oncology Mayo Clinic Arizona Phoenix Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv048"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000239"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyu073"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.6462"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr160"},{"key":"e_1_2_8_8_1","first-page":"374","article-title":"Causes of death in patients with stage 0\u2010II breast cancer","volume":"119","author":"Ursaru M","year":"2015","journal-title":"Rev Med Chir Soc Med Nat Iasi"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_2_8_10_1","unstructured":"Surveillance Research Program National Cancer Institute.SEER*Stat software version 8.3.5. 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