{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:07:19Z","timestamp":1787954839928,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To the authors' knowledge, the question of whether human papillomavirus (HPV) infection is associated with outcomes in patients with sinonasal squamous cell carcinoma (SNSCC) is not well studied at this time. In the current study, the authors investigated patterns of HPV testing and its association with survival in patients with SNSCC using the National Cancer Data Base.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors selected all SNSCC cases diagnosed between 2010 and 2016. HPV testing practices, clinicodemographic factors, treatments, and survival were analyzed. Multivariable Cox regression and propensity score\u2013matched survival analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 6458 SNSCC cases were identified. Of these, only 1523 cases (23.6%) were tested for HPV and included in the current study. The median patient age was 64\u00a0years and the majority had advanced stage tumors (overall AJCC stage III\u2010IV, 721 patients; 62.1%). HPV\u2010positive SNSCC comprised 31.5% (447 of 1418 cases) of the final study cohort. Among 15 hospitals that routinely tested nonoropharyngeal SCCs for HPV, the percentage of HPV\u2010positive SNSCCs was smaller (24.6%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). Patients with HPV\u2010positive SNSCC were younger (aged 60\u00a0years vs 65\u00a0years; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), with tumors that were more likely to be high grade (55.3% vs 41.7%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and attributed to the nasal cavity (62.2% vs 44.0%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). HPV\u2010positive SNSCC was associated with significantly improved overall survival in multivariable regression analysis (hazard ratio, 0.45; 95% CI, 0.28\u20100.72 [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001]) and propensity score\u2013matched (hazard ratio, 0.61; 95% CI, 0.38\u20100.96 [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03]) analyses controlling for clinicodemographic and treatment factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Currently, only a minority of patients with SNSCC are tested for HPV. However, a sizable percentage of SNSCC cases may be HPV related; furthermore, HPV\u2010positive SNSCC is associated with improved overall survival. Routine HPV testing may be warranted in patients with SNSCC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32679","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T09:58:01Z","timestamp":1577699881000},"page":"1413-1423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Human papillomavirus and survival of patients with sinonasal squamous cell carcinoma"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2664-7756","authenticated-orcid":false,"given":"Jamie R.","family":"Oliver","sequence":"first","affiliation":[{"name":"New York University School of Medicine New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth M.","family":"Lieberman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery NYU Langone Health New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2011-4211","authenticated-orcid":false,"given":"Moses M.","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology NYU Langone Health New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng Z.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Langone Health New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zujun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology NYU Langone Health New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4617-739X","authenticated-orcid":false,"given":"Kenneth S.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology NYU Langone Health New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4417-2280","authenticated-orcid":false,"given":"Luc G. 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