{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:45:11Z","timestamp":1790318711858,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T00:00:00Z","timestamp":1578009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["Scholar in Clinical Research (El\u2010Jawahri)"],"award-info":[{"award-number":["Scholar in Clinical Research (El\u2010Jawahri)"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007316","name":"Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"publisher","award":["K12 Career Development Award (El\u2010Jawahri)"],"award-info":[{"award-number":["K12 Career Development Award (El\u2010Jawahri)"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,4,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Caregivers of patients undergoing hematopoietic stem cell transplantation (HCT) experience an immense caregiving burden before, during, and after HCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an unblinded, randomized trial of a psychosocial intervention (BMT\u2010CARE) for caregivers of patients undergoing autologous and allogeneic HCT at Massachusetts General Hospital. Caregivers were randomly assigned to BMT\u2010CARE or usual care. BMT\u2010CARE was tailored to the HCT trajectory and integrated treatment\u2010related education and self\u2010care with cognitive\u2010behavioral skills to promote coping. Caregivers assigned to BMT\u2010CARE met with a trained interventionist (a psychologist or a social worker) in person, via telephone, or via videoconferencing for 6 sessions starting before HCT and continuing up to day +60 after HCT. The primary endpoint was feasibility, which was defined as at least 60% of eligible caregivers enrolling and completing 50% or more of the intervention sessions. We assesed caregiver quality of life (QOL; Caregiver Oncology Quality of Life Questionnaire), caregiving burden (Caregiver Reaction Assessment), psychological distress (Hospital Anxiety and Depression Scale), self\u2010efficacy (Cancer Self\u2010Efficacy Scale\u2013Transplant), and coping (Measures of Current Status) at baseline and 30 and 60\u00a0days after HCT. We used mixed linear effect models to assess the effect of BMT\u2010CARE on outcomes longitudinally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We enrolled 72.5% of eligible caregivers (100 of 138), and 80% attended 50% or more of the intervention sessions. Caregivers randomized to BMT\u2010CARE reported improved QOL (\n                      <jats:italic>B<\/jats:italic>\n                      \u00a0=\u00a06.11; 95% CI, 3.50\u20108.71;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), reduced caregiving burden (\n                      <jats:italic>B<\/jats:italic>\n                      \u00a0=\u00a0\u20136.02; 95% CI, \u20138.49 to \u20133.55;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), lower anxiety (\n                      <jats:italic>B<\/jats:italic>\n                      \u00a0=\u00a0\u20132.18; 95% CI, \u20133.07 to \u20131.28;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and depression symptoms (\n                      <jats:italic>B<\/jats:italic>\n                      \u00a0=\u00a0\u20131.23; 95% CI, \u20131.92 to \u20130.54;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), and improved self\u2010efficacy (\n                      <jats:italic>B<\/jats:italic>\n                      \u00a0=\u00a07.22; 95% CI, 2.40\u201012.03;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.003) and coping skills (\n                      <jats:italic>B<\/jats:italic>\n                      \u00a0=\u00a04.83; 95% CI, 3.04\u20106.94;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) in comparison with the usual\u2010care group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A brief multimodal psychosocial intervention tailored for caregivers of HCT recipients is feasible and may improve QOL, mood, coping, and self\u2010efficacy while reducing the caregiving burden during the acute HCT period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32680","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T08:56:21Z","timestamp":1578041781000},"page":"1758-1765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Multimodal psychosocial intervention for family caregivers of patients undergoing hematopoietic stem cell transplantation: A randomized clinical trial"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3556-1495","authenticated-orcid":false,"given":"Areej","family":"El\u2010Jawahri","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital Boston Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9740-624X","authenticated-orcid":false,"given":"Jamie 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