{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:00:11Z","timestamp":1784098811858,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001439"],"award-info":[{"award-number":["UL1 TR001439"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["PP160097"],"award-info":[{"award-number":["PP160097"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,4,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human papillomavirus (HPV)\u2013related disease remains a significant source of morbidity and mortality, and this underscores the need to increase HPV vaccination to reduce the burden of the disease. The objective of this study was to examine the association between the number of HPV vaccine doses and the risk of histologically confirmed preinvasive cervical disease and high\u2010grade cytology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective matched cohort study used administrative data from Optum's Clinformatics DataMart Database to identify females aged 9 to 26\u00a0years who received 1 or more quadrivalent HPV vaccine doses between January 2006 and June 2015. Cases and controls were matched on region, age, sexually transmitted disease history, and pregnancy. All had a Papanicolaou test \u22651\u00a0year after the date of the matched case's final dose. Cox proportional hazards models were used to examine the association between the number of HPV vaccine doses and the incidence of preinvasive cervical disease and high\u2010grade cytology. The Kaplan\u2010Meier method was used to estimate the cumulative incidence rate at the 5\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 133,082 females (66,541 vaccinated and 66,541 unvaccinated) stratified by the number of HPV vaccine doses and the vaccine initiation age. Among those aged 15 to 19\u00a0years, the hazard ratio (HR) for high\u2010grade cytology for the 3\u2010dose group was 0.84 (95% confidence interval [CI], 0.73\u20100.97), whereas the HRs for histologically confirmed preinvasive cervical disease for 1, 2, and 3 doses were 0.64 (95% CI, 0.47\u20100.88), 0.72 (95% CI, 0.54\u20100.95), and 0.66 (95% CI, 0.55\u20100.80), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The receipt of 1, 2, or 3 doses of an HPV vaccine by females aged 15 to 19\u00a0years was associated with a lower incidence of preinvasive cervical disease in comparison with unvaccinated females, and this supports the use of any HPV vaccination in reducing the burden of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32700","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T03:03:29Z","timestamp":1581303809000},"page":"1656-1667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Comparison of the long\u2010term impact and clinical outcomes of fewer doses and standard doses of human papillomavirus vaccine in the United States: A database study"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5747-6606","authenticated-orcid":false,"given":"Ana M.","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Texas Medical Branch at Galveston Galveston Texas"},{"name":"Sealy Institute for Vaccine Sciences University of Texas Medical Branch at Galveston Galveston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Zeybek","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Department of Obstetrics, Gynecology, and Reproductive Sciences Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micah","family":"Vaughn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Texas Medical Branch at Galveston Galveston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Westra","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Community Health University of Texas Medical Branch at Galveston Galveston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4241-5453","authenticated-orcid":false,"given":"Sapna","family":"Kaul","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Community Health University of Texas Medical Branch at Galveston Galveston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane R.","family":"Montealegre","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dan L. Duncan Comprehensive Cancer Center Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Community Health University of Texas Medical Branch at Galveston Galveston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Fang","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Community Health University of Texas Medical Branch at Galveston Galveston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e318286bb53"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8572065"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0410"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2012.10.024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4033-2"},{"key":"e_1_2_8_7_1","first-page":"CD009069","article-title":"Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors","volume":"5","author":"Arbyn M","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28963"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.06.033"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/597309"},{"key":"e_1_2_8_11_1","first-page":"300","article-title":"Use of 9\u2010valent human papillomavirus (HPV) vaccine: updated HPV vaccination recommendations of the Advisory Committee on Immunization Practices","volume":"64","author":"Petrosky E","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1146429"},{"key":"e_1_2_8_13_1","unstructured":"Centers for Disease Control and Prevention.Clinician FAQs: CDC recommendations for HPV vaccine 2\u2010dose schedule. 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