{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T23:00:03Z","timestamp":1772319603457,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"S9","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.: 81772579"],"award-info":[{"award-number":["No.: 81772579"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Imatinib is the standard treatment for patients with gastrointestinal stromal tumors (GISTs), but there is significant variation in imatinib plasma trough concentrations (C<jats:sub>min<\/jats:sub>) among patients. The imatinib C<jats:sub>min<\/jats:sub> distribution at different doses and the correlation of adverse reactions with C<jats:sub>min<\/jats:sub> in Chinese patients with GIST from a high\u2010volume center were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From July 1, 2017 to December 31, 2018, patients who were receiving imatinib treatment for GIST were prospectively enrolled. Steady\u2010state blood samples were obtained from patients who had received same\u2010dose imatinib treatment for \u22651\u00a0month with good compliance. Adverse reactions were recorded during regular follow\u2010up, and blood samples were collected 24\u00a0\u00b1\u00a02\u00a0hours after dosing. Liquid chromatography\u2010tandem mass spectrometry was used to measure drug concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 307 patients who received 367 dose levels were investigated. The imatinib C<jats:sub>min<\/jats:sub> was 1315\u00a0\u00b1\u00a0716\u00a0ng\/mL, 2117\u00a0\u00b1\u00a0597\u00a0ng\/mL, and 3844\u00a0\u00b1\u00a0987\u00a0ng\/mL in patients who were receiving imatinib 400\u00a0mg, 600\u00a0mg, and 800\u00a0mg daily, respectively. The C<jats:sub>min<\/jats:sub> was significantly correlated with periorbital and limb edema (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), anemia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and rash (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.037). Nausea and vomiting, diarrhea, and conjunctival hemorrhage also were correlated, but not significantly. A much higher C<jats:sub>min<\/jats:sub> was observed with severe adverse reactions. There was no correlation between the imatinib C<jats:sub>min<\/jats:sub> and leukopenia, muscle cramps, or hepatobiliary dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In Chinese patients with GIST, the imatinib C<jats:sub>min<\/jats:sub> was higher than that reported for Western populations, especially at higher doses. The C<jats:sub>min<\/jats:sub> was correlated with periorbital and limb edema, anemia, and rash, suggesting that monitoring the imatinib C<jats:sub>min<\/jats:sub> should be considered when patients develop severe adverse reactions caused by excessive imatinib plasma concentrations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32751","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T10:37:20Z","timestamp":1586947040000},"page":"2054-2061","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Correlations between imatinib plasma trough concentration and adverse reactions in Chinese patients with gastrointestinal stromal tumors"],"prefix":"10.1002","volume":"126","author":[{"given":"Yanzhe","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Pharmacy The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou 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