{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:59:21Z","timestamp":1784260761709,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Proton therapy (PT) improves outcomes in patients with nasal cavity (NC) and paranasal sinus (PNS) cancers. Herein, the authors have reported to their knowledge the largest series to date using intensity\u2010modulated proton therapy (IMPT) in the treatment of these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between 2013 and 2018, a total of 86 consecutive patients (68 of whom were radiation\u2010naive and 18 of whom were reirradiated) received PT to median doses of 70\u00a0grays and 67\u00a0grays relative biological effectiveness, respectively. Approximately 53% received IMPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median follow\u2010up was 23.4\u00a0months (range, 1.7\u201069.3\u00a0months) for all patients and 28.1\u00a0months (range, 2.3\u201069.3\u00a0months) for surviving patients. The 2\u2010year local control (LC), distant control, disease\u2010free survival, and overall survival rates were 83%, 84%, 74%, and 81%, respectively, for radiation\u2010naive patients and 77%, 80%, 54%, and 66%, respectively for reirradiated patients. Among radiation\u2010naive patients, when compared with 3\u2010dimensional conformal proton technique, IMPT significantly improved LC (91% vs 72%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.01) and independently predicted LC (hazard ratio, 0.14;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01). Sixteen radiation\u2010naive patients (24%) experienced acute grade 3 toxicities; 4 (6%) experienced late grade 3 toxicities (osteoradionecrosis, vision loss, soft\u2010tissue necrosis, and soft tissue fibrosis) (grading was performed according to the National Cancer Institute Common Terminology Criteria for Adverse Events [version 5.0]). Slightly inferior LC was noted for patients undergoing reirradiation with higher complications: 11% experienced late grade 3 toxicities (facial pain and brain necrosis). Patients treated with reirradiation had more grade 1 to 2 radionecrosis than radiation\u2010naive patients (brain: 33% vs 7% and osteoradionecrosis: 17% vs 3%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PT achieved remarkable LC for patients with nasal cavity and paranasal sinus cancers with lower grade 3 toxicities relative to historical reports. IMPT has the potential to improve the therapeutic ratio in these malignancies and is worthy of further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32776","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T16:24:11Z","timestamp":1582647851000},"page":"1905-1916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Outcomes and toxicities of definitive radiotherapy and reirradiation using 3\u2010dimensional conformal or intensity\u2010modulated (pencil beam) proton therapy for patients with nasal cavity and paranasal sinus malignancies"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8676-2716","authenticated-orcid":false,"given":"Ming","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York New York"},{"name":"Department of 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