{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:08:51Z","timestamp":1788548931713,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["#IRG\u201058\u2010009\u201056"],"award-info":[{"award-number":["#IRG\u201058\u2010009\u201056"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000445"],"award-info":[{"award-number":["UL1 TR000445"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K07CA218247"],"award-info":[{"award-number":["K07CA218247"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human papillomavirus 16 (HPV\u201016) E6 seropositivity is a promising early marker of human papillomavirus\u2013driven oropharyngeal cancer (HPV\u2010OPC), yet more sensitive imaging modalities are needed before screening is considered. The objective of this study was to determine the sensitivity of transcervical sonography (TCS) for detecting clinically apparent HPV\u2010OPC in comparison with computed tomography (CT) and positron emission tomography (PET)\/CT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010one patients with known or suspected HPV\u2010OPC without prior treatment underwent oropharyngeal TCS and blood collection (for HPV multiplex serology testing). Eight standard sonographic images were collected; primary\u2010site tumors were measured in 3 dimensions if identified. Each patient underwent a full diagnostic workup as part of standard clinical care. The pathologic details, HPV status, final staging, and imaging findings were abstracted from the medical record. The sensitivity of each imaging modality was compared with the final clinical diagnosis (the gold standard).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010four base of tongue cancers (47%), 22 tonsillar cancers (43%), and 2 unknown primary cancers (4%) were diagnosed; 3 patients (6%) had no tumors. All p16\u2010tested patients were positive (n\u00a0=\u00a047). Primary\u2010site tumors were correctly identified in 90.2% (95% confidence interval [CI], 78.6%\u201096.7%) with TCS, in 69.4% (95% CI, 54.6%\u201081.7%) with CT, and in 83.3% (95% CI, 68.6%\u201093.0%) with PET\/CT. TCS identified tumors in 10 of 14 cases missed by CT and recognized the absence of tumors in 3 cases for which CT or PET\/CT was falsely positive. The smallest sonographically identified primary\u2010site tumor was 0.5\u00a0cm in its greatest dimension; the average size was 2.3\u00a0cm. Among p16\u2010positive patients, 76.1% (95% CI, 61.2%\u201087.4%) were seropositive for HPV\u201016 E6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TCS and HPV\u201016 E6 antibodies are sensitive for the diagnosis of HPV\u2010OPC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32799","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T09:55:29Z","timestamp":1583315729000},"page":"2658-2665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Transcervical sonography and human papillomavirus 16 E6 antibodies are sensitive for the detection of oropharyngeal cancer"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7643-9330","authenticated-orcid":false,"given":"Krystle A.","family":"Lang Kuhs","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Burton","family":"Wood","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Wiggleton","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Aulino","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Latimer","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek K.","family":"Smith","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville 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