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In the current study, the authors investigated whether patients expressed regret after undergoing HCT and the relationships between clinical outcomes and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy\u2013Bone Marrow Transplant (FACT\u2010BMT) before undergoing alloHCT and at day 100 were used. Additional time points were 6\u00a0months and 12\u00a0months. Regret was measured using a FACT\u2010BMT item not included in scoring: \u201cI regret having the bone marrow transplant.\u201d The authors evaluated FACT\u2010BMT scores and regret using Student\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests. Covariance pattern models were used to determine predictors of regret over time, including baseline characteristics and post\u2010alloHCT outcomes (acute or chronic graft\u2010versus\u2010host\u2010disease, disease recurrence).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 100\u00a0days, 6\u00a0months, and 12\u00a0months, approximately 6% to 8% of patients expressed regret; a total of 15% expressed regret at any time point. Regret was found to be associated with lower FACT\u2010BMT scores at 6\u00a0months and 12\u00a0months (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Higher baseline FACT\u2010BMT and social well\u2010being scores were associated with a reduced risk of expressing regret. The risk of regretting transplantation was 17.5 percentage points (95% confidence interval, 5.5\u201029.7 percentage points) greater in patients who developed disease recurrence after HCT compared with patients who did not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among patients who underwent alloHCT and lived to 100\u00a0days, the majority did not report regretting their transplantation. Regret was found to be related to disease recurrence. Social connectedness may serve as a protective factor against later regret. Future work should explore regret in other patient groups and use qualitative methods to inform best practices for reducing regret.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32808","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T08:57:53Z","timestamp":1583830673000},"page":"2679-2686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6252-6516","authenticated-orcid":false,"given":"Rachel N.","family":"Cusatis","sequence":"first","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research (CIBMTR) Department of Medicine Medical College of Wisconsin Milwaukee 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