{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:19:22Z","timestamp":1785161962423,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,6,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Clinical experience is limited for primary central nervous system (CNS) lymphoma that arises from the dura mater, which is denoted with the term\n                      <jats:italic>primary dural lymphoma<\/jats:italic>\n                      (PDL). This study was aimed at determining the relative incidence, presentation, and outcomes of PDL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The institutional databases of the Divisions of Neuro\u2010Oncology at the Massachusetts General Hospital and the Yale School of Medicine were retrospectively searched for patients with primary CNS lymphoma. Patients with pathologically confirmed dural lymphoma and no evidence of primary cerebral or systemic involvement were identified. Clinical data, diagnostic findings, treatments, and outcomes were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 20 patients with PDL were identified, and they represented 6.3% of the individuals with primary CNS lymphomas (20 of 316). Histopathological examination of PDL revealed the following underlying subtypes: diffuse large B\u2010cell lymphoma (10 of 20 patients), marginal zone lymphoma (6 of 20), follicular lymphoma (2 of 20), undefined B\u2010cell non\u2010Hodgkin lymphoma (1 of 20), and T\u2010cell non\u2010Hodgkin lymphoma (1 of 20). On imaging, all tumors appeared as extra\u2010axial masses with avid contrast enhancement and mostly mimicked meningioma. The median apparent diffusion coefficient value was 667\u00a0\u00b1\u00a026\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s. Cerebrospinal fluid analyses and symptoms were nonspecific, and the diagnosis rested on tissue analysis. Therapeutic approaches included surgery, radiotherapy, and chemotherapy. The median overall survival was not reached after 5\u00a0years. Three patients were deceased at database closure because of tumor progression. The extent of tumor resection correlated positively with overall survival (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.044).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PDL is a rare variant of primary CNS lymphoma that can be radiographically mistaken for meningioma. The outcome is excellent with multimodality treatment, and aggressive surgery may convey a survival advantage in select cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32834","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T09:07:37Z","timestamp":1584349657000},"page":"2811-2820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Primary dural lymphomas: Clinical presentation, management, and outcome"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1254-5310","authenticated-orcid":false,"given":"Philipp","family":"Karschnia","sequence":"first","affiliation":[{"name":"Division of Neuro\u2010Oncology Department of Neurology Massachusetts General Hospital Cancer Center Harvard Medical School Boston Massachusetts"},{"name":"Department of Neurology Yale School of Medicine New Haven Connecticut"},{"name":"Department of Neurosurgery Ludwig Maximilian University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy T.","family":"Batchelor","sequence":"additional","affiliation":[{"name":"Division of Neuro\u2010Oncology Department of Neurology Massachusetts General Hospital Cancer Center Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin T.","family":"Jordan","sequence":"additional","affiliation":[{"name":"Division of Neuro\u2010Oncology Department of Neurology Massachusetts General Hospital Cancer Center Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Shaw","sequence":"additional","affiliation":[{"name":"Division of Neuro\u2010Oncology Department of Neurology Massachusetts General Hospital Cancer Center Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian F.","family":"Winter","sequence":"additional","affiliation":[{"name":"Division of Neuro\u2010Oncology Department of Neurology Massachusetts General Hospital Cancer Center Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Barbiero","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5937-3376","authenticated-orcid":false,"given":"Leon D.","family":"Kaulen","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Thon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Ludwig Maximilian University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg\u2010Christian","family":"Tonn","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Ludwig Maximilian University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita J.","family":"Huttner","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Fulbright","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Massachusetts General Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorg","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Division of Neuro\u2010Oncology Department of Neurology Massachusetts General Hospital Cancer Center Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim M.","family":"Baehring","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox158"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000218284.23872.eb"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1218006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00076-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.13.524"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.4342"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_8_9_1","first-page":"722","article-title":"Immunohistochemical expression of CD23 and CD40 may identify prognostically favorable subgroups of diffuse large B\u2010cell lymphoma: a Nordic Lymphoma Group Study","volume":"9","author":"Linderoth J","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx025"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos159"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2006.21.5.6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001457"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30321-7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70190-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov285"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0872"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx103"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox112"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-014-1530-2"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2012.731526"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.2.JNS091554"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00267"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.1455"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-019-03208-w"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.82"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.32834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.32834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.32834","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.32834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:13:36Z","timestamp":1761862416000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.32834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,16]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,6,15]]}},"alternative-id":["10.1002\/cncr.32834"],"URL":"https:\/\/doi.org\/10.1002\/cncr.32834","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,16]]},"assertion":[{"value":"2019-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}