{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T05:51:43Z","timestamp":1793771503195,"version":"4.6.1"},"reference-count":31,"publisher":"Wiley","issue":"S16","license":[{"start":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T00:00:00Z","timestamp":1595635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Clinical Medicine Plus X - Young Scholars Project","award":["PKU2019LCXQ019 and PKU2018LCXQ004"],"award-info":[{"award-number":["PKU2019LCXQ019 and PKU2018LCXQ004"]}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"crossref","award":["7202212"],"award-info":[{"award-number":["7202212"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006739","name":"Capital Foundation of Medical Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006739","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,8,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although traditional intraoperative assessments (ie, frozen sections) may lower reoperation rates in patients with breast cancer, time\/tissue limitations and accuracy concerns have discouraged their routine clinical use. Full\u2010field optical coherence tomography (FFOCT) and dynamic cell imaging (DCI) are novel optical imaging techniques offering rapid histologic approximations that are unfettered by requisite handling steps. This study was conducted to determine the feasibility and diagnostic utility of FFOCT and DCI in examining breast and lymph node specimens during breast cancer surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>FFOCT and DCI were applied to normal and cancerous breast tissue, benign breast lesions, and resected axillary lymph nodes. The tissues were then subjected to conventional processing and staining (hematoxylin\u2010eosin) for purposes of comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 314 specimens, including 173 breast biopsies (malignant, 132; benign\/normal, 41) and 141 resected lymph nodes (tumor\u2010positive, 48; tumor\u2010negative, 93), were obtained from 158 patients during breast surgery for prospective imaging evaluations. In breast cancer diagnosis, the minimum sensitivities (FFOCT, 85.6%; DCI, 88.6%) and specificities of optical imaging (FFOCT, 85.4%; DCI, 95.1%) were high, although they diverged somewhat in nodal assessments (FFOCT sensitivity, 66.7%; FFOCT specificity, 79.6%; DCI sensitivity, 83.3%; DCI specificity, 98.9%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These timely and tissue\u2010sparing optical imaging techniques proved highly accurate in diagnosing breast cancer and nodal metastasis. They compare favorably with routine histologic sections and demonstrate their promise in this setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32838","type":"journal-article","created":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T09:56:17Z","timestamp":1595670977000},"page":"3847-3856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Use of high\u2010resolution full\u2010field optical coherence tomography and dynamic cell imaging for rapid intraoperative diagnosis during breast cancer surgery"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5098-814X","authenticated-orcid":false,"given":"Houpu","family":"Yang","sequence":"first","affiliation":[{"name":"Breast Center Peking University People's Hospital Beijing People's Republic of 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