{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:05:57Z","timestamp":1785236757785,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R37 CA 222866"],"award-info":[{"award-number":["R37 CA 222866"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 HX001574"],"award-info":[{"award-number":["I01 HX001574"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Initiating screening at an earlier age based on cancer family history is one of the primary recommended strategies for the prevention and detection of early\u2010onset colorectal cancer (EOCRC), but data supporting the effectiveness of this approach are limited. The authors assessed the performance of family history\u2013based guidelines for identifying individuals with EOCRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The authors conducted a population\u2010based, case\u2010control study of individuals aged 40 to 49\u00a0years with (2473 individuals) and without (772 individuals) incident CRC in the Colon Cancer Family Registry from 1998 through 2007. They estimated the sensitivity and specificity of family history\u2013based criteria jointly recommended by the American Cancer Society, the US Multi\u2010Society Task Force on CRC, and the American College of Radiology in 2008 for early screening, and the age at which each participant could have been recommended screening initiation if these criteria had been applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Family history\u2013based early screening criteria were met by approximately 25% of cases (614 of 2473 cases) and 10% of controls (74 of 772 controls), with a sensitivity of 25% and a specificity of 90% for identifying EOCRC cases aged 40 to 49\u00a0years. Among 614 individuals meeting early screening criteria, 98.4% could have been recommended screening initiation at an age younger than the observed age of diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Of CRC cases aged 40 to 49\u00a0years, 1 in 4 met family history\u2013based early screening criteria, and nearly all cases who met these criteria could have had CRC diagnosed earlier (or possibly even prevented) if earlier screening had been implemented as per family history\u2013based guidelines. Additional strategies are needed to improve the detection and prevention of EOCRC for individuals not meeting family history criteria for early screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.32851","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T04:39:13Z","timestamp":1587357553000},"page":"3013-3020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Potential impact of family history\u2013based screening guidelines on the detection of early\u2010onset colorectal cancer"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-5002","authenticated-orcid":false,"given":"Samir","family":"Gupta","sequence":"first","affiliation":[{"name":"Section of Gastroenterology San Diego Veterans Affairs Healthcare System San Diego California"},{"name":"Department of Medicine University of California at San Diego La Jolla California"},{"name":"Moores Cancer Center University of California at San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balambal","family":"Bharti","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California at San Diego La Jolla California"},{"name":"Moores Cancer Center University of California at San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis J.","family":"Ahnen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology &amp; Hepatology University of Colorado Anschutz Medical Center Aurora Colorado"},{"name":"Gastroenterology of the Rockies Boulder Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Colorectal Oncogenomics Group Department of Clinical Pathology The University of Melbourne Parkville Victoria Australia"},{"name":"University of Melbourne Centre for Cancer Research Victorian Comprehensive Cancer Centre Parkville Victoria Australia"},{"name":"Genomic Medicine and Family Cancer Clinic Royal Melbourne Hospital Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iona C.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Cotterchio","sequence":"additional","affiliation":[{"name":"Prevention and Cancer Control, Cancer Care Ontario Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2452-3194","authenticated-orcid":false,"given":"Jane C.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Medicine Samuel Oschin Comprehensive Cancer Institute, Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Gallinger","sequence":"additional","affiliation":[{"name":"Department of Surgery Mount Sinai Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Haile","sequence":"additional","affiliation":[{"name":"Department of Medicine Samuel Oschin Comprehensive Cancer Institute, Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"University of Melbourne Centre for Cancer Research Victorian Comprehensive Cancer Centre Parkville Victoria Australia"},{"name":"Centre for Epidemiology and Biostatistics School of Population and Global Health The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noralane M.","family":"Lindor","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Scottsdale Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finlay A.","family":"Macrae","sequence":"additional","affiliation":[{"name":"Colorectal Medicine and Genetics, Department of Medicine University of Melbourne The Royal Melbourne Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Le Marchand","sequence":"additional","affiliation":[{"name":"Epidemiology Program Research Cancer Center of Hawaii University of Hawaii Honolulu Hawaii"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly A.","family":"Newcomb","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle 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