{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:50:04Z","timestamp":1791111004284,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA174452"],"award-info":[{"award-number":["R01CA174452"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,7,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Survivors of childhood brain tumors experience persistent health concerns across their lifespan. In the current study, the authors evaluated changes in symptom burden over the course of 12\u00a0months using pediatric Patient\u2010Reported Outcomes Measurement Information System (PROMIS) measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 202 survivors aged 8 to 21\u00a0years and 262 parents of survivors who were aged 5 to 21\u00a0years were analyzed. All completed a PROMIS Cognition short form and computerized adaptive tests of pediatric Anxiety, Depressive Symptoms, Fatigue, Mobility, Upper Extremity Function, and Peer Relationships. Approximately one\u2010half of participants (223 participants: 97 survivors of childhood brain tumors and 126 parents) completed the 12\u2010month follow\u2010up. Linear mixed\u2010effects models evaluated group\u2010level symptoms over time. Cox proportional hazard models explored whether symptoms predicted survival, and latent class growth analysis investigated patterns of individual\u2010level symptom changes over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Linear mixed\u2010effects models demonstrated that patient\u2010reported Cognition and parent\u2010reported Anxiety worsened over time. Latent class growth analysis results indicated that patient and parent reports diverged, both with regard to the number of classes identified and in the trends of these classes. Parents and patients reported similar patterns of depression over time. For the other areas, parents either were more likely to observe different patterns (Peer Relationships and Mobility) or less likely to observe different patterns (Upper Extremity Function, Cognition, Anxiety, and Fatigue). Baseline patient\u2010reported Mobility and Upper Extremity Function were found to be associated with survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Survivors of childhood brain tumors demonstrated different trajectory patterns of symptom burden. Along with baseline functioning status and days since treatment, patient\u2010reported Mobility and Upper Extremity Function were associated with survival, suggesting a possible role for patient\u2010reported outcomes in clinical care, especially individualized, tailored assessments such as PROMIS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32879","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T11:06:53Z","timestamp":1588763213000},"page":"3341-3351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Symptom burden trajectories experienced by patients with brain tumors"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1840-2537","authenticated-orcid":false,"given":"Jin\u2010Shei","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Medical Social Sciences Feinberg School of Medicine Northwestern University Chicago Illinois"},{"name":"Department of Pediatrics Feinberg School of Medicine, Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Beaumont","sequence":"additional","affiliation":[{"name":"Department of Medical Social Sciences Feinberg School of Medicine Northwestern University Chicago Illinois"},{"name":"Biostatistics, Clinical Outcomes Solutions Tucson Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jo","family":"Kupst","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5762-7881","authenticated-orcid":false,"given":"John Devin","family":"Peipert","sequence":"additional","affiliation":[{"name":"Department of Medical Social Sciences Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cella","sequence":"additional","affiliation":[{"name":"Department of Medical Social Sciences Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison Piazza","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Medical Social Sciences Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Goldman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Feinberg School of Medicine, Northwestern University Chicago Illinois"},{"name":"Division of Hematology, Oncology Neuro\u2010Oncology and Stem Cell Transplantation Ann and Robert H. 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