{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:45:14Z","timestamp":1790937914809,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,7,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of race on prostate cancer skeletal\u2010related events (SREs) remains understudied. In the current study, the authors tested the impact of race on time to SREs and overall survival in men with newly diagnosed, bone metastatic castration\u2010resistant prostate cancer (mCRPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors performed a retrospective study of patients from 8 Veterans Affairs hospitals who were newly diagnosed with bone mCRPC in the year 2000 or later. SREs comprised pathologic fracture, spinal cord compression, radiotherapy to the bone, or surgery to the bone. Time from diagnosis of bone mCRPC to SREs and overall mortality was estimated using the Kaplan\u2010Meier method. Cox models tested the association between race and SREs and overall mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 837 patients with bone mCRPC, 232 patients (28%) were black and 605 (72%) were nonblack. At the time of diagnosis of bone mCRPC, black men were found to be more likely to have more bone metastases compared with nonblack men (29% vs 19% with \u226510 bone metastases; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.021) and to have higher prostate\u2010specific antigen (41.7\u00a0ng\/mL vs 29.2\u00a0ng\/mL; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005) and a longer time from the diagnosis of CRPC to metastasis (17.9\u00a0months vs 14.3\u00a0months; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). On multivariable analysis, there were no differences noted with regard to SRE risk (hazard ratio [HR], 0.80; 95% CI, 0.59\u20101.07) or overall mortality (HR, 0.87; 95% CI, 0.73\u20101.04) between black and nonblack people, although the HRs were &lt;1, which suggested the possibility of better outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No significant association between black race and risk of SREs and overall mortality was observed in the current study. These data have suggested that efforts to understand the basis for the excess risk of aggressive prostate cancer in black men should focus on cancer development and progression in individuals with early\u2010stage disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32933","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T11:08:22Z","timestamp":1588763302000},"page":"3274-3280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Race does not predict skeletal\u2010related events and all\u2010cause mortality in men with castration\u2010resistant prostate cancer"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9764-5870","authenticated-orcid":false,"given":"Devin N.","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Urology Department of Surgery Samuel Oschin Comprehensive Cancer Institute, Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3355-4483","authenticated-orcid":false,"given":"Lauren E.","family":"Howard","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Duke University School of Medicine Durham North Carolina USA"},{"name":"Division of Urology Veterans Affairs Medical Center Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3899-7702","authenticated-orcid":false,"given":"Amanda M.","family":"De Hoedt","sequence":"additional","affiliation":[{"name":"Division of Urology Veterans Affairs Medical Center Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6559-3340","authenticated-orcid":false,"given":"Christopher L.","family":"Amling","sequence":"additional","affiliation":[{"name":"Department of Urology Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Aronson","sequence":"additional","affiliation":[{"name":"Department of Urology University of California at Los Angeles School of Medicine Los Angeles California USA"},{"name":"Urology Section, Department of Surgery Veterans Affairs Greater Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4339-6685","authenticated-orcid":false,"given":"Matthew R.","family":"Cooperberg","sequence":"additional","affiliation":[{"name":"Department of Urology University of California at San Francisco Helen Diller Family Comprehensive Cancer Center San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Kane","sequence":"additional","affiliation":[{"name":"Urology Department University of California at San Diego Health System San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary W.","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Section of Urology Veterans Affairs Medical Center Augusta Georgia USA"},{"name":"Section of Urology Augusta University Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3843-7270","authenticated-orcid":false,"given":"Martha K.","family":"Terris","sequence":"additional","affiliation":[{"name":"Section of Urology Veterans Affairs Medical Center Augusta Georgia USA"},{"name":"Section of Urology Augusta University Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8104-6419","authenticated-orcid":false,"given":"Stephen J.","family":"Freedland","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Samuel Oschin Comprehensive Cancer Institute, Cedars\u2010Sinai Medical Center Los 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