{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:12:59Z","timestamp":1792649579143,"version":"4.5.0"},"reference-count":107,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002378"],"award-info":[{"award-number":["UL1TR002378"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH117009"],"award-info":[{"award-number":["R01MH117009"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K12HD085850"],"award-info":[{"award-number":["K12HD085850"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,7,15]]},"abstract":"<jats:p>A breast cancer diagnosis can be a life\u2010changing and stressful experience that can lead to chronic mental health conditions such as posttraumatic stress disorder (PTSD). Greater than one\u2010third of patients initially diagnosed with PTSD after a diagnosis of breast cancer continue to have persistent or worsening PTSD symptoms after 4\u00a0years. An emerging body of literature has indicated several key environmental and biological risk factors for PTSD among survivors of breast cancer. Well\u2010recognized risk factors include having a history of childhood trauma, being nonwhite, obesity, younger age at the time of diagnosis, diagnosis with a higher stage of breast cancer, and short time since treatment. Of the emerging risk factors related to fear circuitry in the brain, 2 pathways of particular importance are the stress\u2010driven activation of inflammatory pathways and the long\u2010term effect of antiendocrine therapies. These central and peripheral responses during and after stress exposure are important because increased fear and anxiety can lead to the maintenance of PTSD and worse patient outcomes. Given the poor outcomes associated with PTSD and the high prevalence of breast cancer in women, more research to identify those women at heightened risk of PTSD after breast cancer is warranted to reduce the number of diagnoses and lessen the negative impact of this chronic mental health condition.<\/jats:p>","DOI":"10.1002\/cncr.32934","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T11:06:40Z","timestamp":1588763200000},"page":"3181-3191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Posttraumatic stress disorder and breast cancer: Risk factors and the role of inflammation and endocrine function"],"prefix":"10.1002","volume":"126","author":[{"given":"Lauren C.","family":"Brown","sequence":"first","affiliation":[{"name":"Emory University College of Arts and Sciences Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy R.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6775-3299","authenticated-orcid":false,"given":"Chloe S.","family":"Lalonde","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti D.","family":"Subhedar","sequence":"additional","affiliation":[{"name":"Glenn Family Breast Center Winship Cancer Institute Emory University Atlanta Georgia USA"},{"name":"Department of Surgery Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA"},{"name":"Glenn Family Breast Center Winship Cancer Institute Emory University Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4674-0314","authenticated-orcid":false,"given":"Jennifer S.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA"},{"name":"Glenn Family Breast Center Winship Cancer Institute Emory University Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0025989"},{"issue":"5","key":"e_1_2_4_4_1","first-page":"4","article-title":"Posttraumatic stress disorder: the burden to the individual and to society","volume":"61","author":"Kessler RC","year":"2000","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1995.03950240066012"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20073"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22345"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-015-0032-7"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/BCTT.S111101"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10880-007-9083-6"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22542"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0803"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30980"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024490718043"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/bec.2014.26"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2007.10.008"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1057"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.20316"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.8941"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3367"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-004-0799-4"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.157834"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3654"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.2631"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.10.014"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-017-0140-9"},{"key":"e_1_2_4_28_1","first-page":"1533","article-title":"Prevalence of posttraumatic stress disorder among breast cancer patients: a meta\u2010analysis","volume":"45","author":"Wu X","year":"2016","journal-title":"Iran J Public Health"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt024"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.6.902"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-010-0136-8"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15324796ABM2501_03"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-013-0272-z"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1481"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3623"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291710000401"},{"key":"e_1_2_4_37_1","first-page":"336","article-title":"The black mask of humanity: racial\/ethnic discrimination and post\u2010traumatic stress disorder","volume":"30","author":"Butts HF","year":"2002","journal-title":"J Am Acad Psychiatry Law"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-016-0737-9"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20599"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/15299730802624585"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.111"},{"key":"e_1_2_4_42_1","article-title":"Chronic pain and chronic stress: two sides of the same coin?","volume":"1","author":"Abdallah CG","year":"2017","journal-title":"Chronic Stress (Thousand Oaks)"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.10.142"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3831"},{"key":"e_1_2_4_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.01.035"},{"key":"e_1_2_4_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-014-0504-2"},{"key":"e_1_2_4_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-017-2035-6"},{"key":"e_1_2_4_48_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951511000897"},{"key":"e_1_2_4_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"key":"e_1_2_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"e_1_2_4_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56218-z"},{"key":"e_1_2_4_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgv123"},{"key":"e_1_2_4_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.01.004"},{"key":"e_1_2_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00309-0"},{"key":"e_1_2_4_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.146"},{"key":"e_1_2_4_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.11.029"},{"key":"e_1_2_4_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37334-8"},{"key":"e_1_2_4_58_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0522"},{"key":"e_1_2_4_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3978"},{"key":"e_1_2_4_60_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2398"},{"key":"e_1_2_4_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.09.010"},{"key":"e_1_2_4_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70263-3"},{"key":"e_1_2_4_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2007.09.006"},{"key":"e_1_2_4_64_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0070"},{"key":"e_1_2_4_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/YPG.0000000000000143"},{"key":"e_1_2_4_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2016.07.005"},{"key":"e_1_2_4_67_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.17.3172"},{"key":"e_1_2_4_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)01196-0"},{"key":"e_1_2_4_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2004.08.005"},{"key":"e_1_2_4_70_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951512000636"},{"key":"e_1_2_4_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088099"},{"key":"e_1_2_4_72_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.189164"},{"key":"e_1_2_4_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.03.031"},{"key":"e_1_2_4_74_1","first-page":"4309","article-title":"Fulvestrant in postmenopausal women with advanced breast cancer","volume":"9","author":"Bross PF","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_4_75_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0532"},{"key":"e_1_2_4_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2009.05.008"},{"key":"e_1_2_4_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23600"},{"key":"e_1_2_4_78_1","doi-asserted-by":"publisher","DOI":"10.1080\/07347332.2015.1019661"},{"key":"e_1_2_4_79_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986713804999303"},{"key":"e_1_2_4_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2014.03.003"},{"key":"e_1_2_4_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001095"},{"key":"e_1_2_4_82_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023246"},{"key":"e_1_2_4_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2008.04.014"},{"key":"e_1_2_4_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301067"},{"key":"e_1_2_4_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.08.005"},{"key":"e_1_2_4_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(07)67011-3"},{"key":"e_1_2_4_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.11.015"},{"key":"e_1_2_4_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.257"},{"key":"e_1_2_4_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.02.007"},{"key":"e_1_2_4_90_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000138"},{"key":"e_1_2_4_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09088-8"},{"key":"e_1_2_4_92_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.3.6.535"},{"key":"e_1_2_4_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz298"},{"key":"e_1_2_4_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-4-68"},{"key":"e_1_2_4_95_1","volume-title":"The Psychobiology of Trauma and Resilience Across the Lifespan","author":"Delahanty DL","year":"2008"},{"key":"e_1_2_4_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12576-w"},{"key":"e_1_2_4_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.77"},{"key":"e_1_2_4_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0447-7"},{"key":"e_1_2_4_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(96)00174-2"},{"key":"e_1_2_4_100_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15547"},{"key":"e_1_2_4_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2000"},{"key":"e_1_2_4_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2007.00571.x"},{"key":"e_1_2_4_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq153"},{"key":"e_1_2_4_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-10-242"},{"key":"e_1_2_4_105_1","doi-asserted-by":"publisher","DOI":"10.1037\/e553842013-001"},{"key":"e_1_2_4_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2585-z"},{"key":"e_1_2_4_107_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c693"},{"key":"e_1_2_4_108_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.3266"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.32934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.32934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.32934","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.32934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T21:40:22Z","timestamp":1760305222000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.32934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,6]]},"references-count":107,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2020,7,15]]}},"alternative-id":["10.1002\/cncr.32934"],"URL":"https:\/\/doi.org\/10.1002\/cncr.32934","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,6]]},"assertion":[{"value":"2019-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}