{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:42:19Z","timestamp":1785148939042,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010term treatment\u2010free remission (TFR) represents a new goal for chronic myeloid leukemia (CML). In clinical practice, tyrosine kinase inhibitor (TKI) dose reductions can be considered a means of preventing adverse effects and improving quality of life. We hypothesized that administration of low\u2010dose TKIs before treatment discontinuation does not impair TFR in patients with CML who have a deep molecular response (DMR, \u2265MR<jats:sup>4<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis of 77 patients with CML who discontinued treatment with TKIs. Twenty\u2010six patients had been managed with low\u2010dose TKIs before stopping treatment. Patients were to be exposed to TKIs for \u22655\u00a0years and to low\u2010dose TKIs for \u22651\u00a0year and in DMR for \u22652\u00a0years. The loss of major molecular response (MMR) was considered a trigger for restarting therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the low\u2010dose group, 61.5% of patients received second\u2010generation TKIs, and dose reduction was \u226550% for 65.4% of patients. With a median follow\u2010up of 61.5\u00a0months, TFR at 12\u00a0months was 56.8% in the full\u2010dose TKI group and 80.8% in the low\u2010dose group, and TFR at 60\u00a0months was 47.5% and 58.8%, respectively. The median time to molecular recurrence (\u2265MMR) from TKI discontinuation in the entire cohort was 6.2\u00a0months. All patients quickly achieved MMR after resuming TKI therapy. Results appear independent of both dose reduction and potential pretreatment with interferon\u2010\u03b1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This retrospective study shows that TFR was not impaired by low\u2010dose TKI regimens before TKI cessation in Patients with CML. Nevertheless, prospective randomized clinical trials must be undertaken to analyze the probability of successful TFR in patients managed with TKI dose de\u2010escalation strategies before TKI discontinuation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.32940","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T09:21:08Z","timestamp":1590571268000},"page":"3438-3447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Low\u2010dose tyrosine kinase inhibitors before treatment discontinuation do not impair treatment\u2010free remission in chronic myeloid leukemia patients: Results of a retrospective study"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1654-5948","authenticated-orcid":false,"given":"Emilie","family":"Cayssials","sequence":"first","affiliation":[{"name":"Service d'Oncologie H\u00e9matologique et Th\u00e9rapie Cellulaire, CHU 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