{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:14:21Z","timestamp":1791900861287,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["T32HS026120"],"award-info":[{"award-number":["T32HS026120"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>New York City (NYC) is the epicenter of severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019 [COVID\u201019]) in the United States. Clinical characteristics and outcomes of vulnerable populations, such as those with gynecologic cancer who develop COVID\u201019 infections, is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients from 6 NYC\u2010area hospital systems with known gynecologic cancer and a COVID\u201019 diagnosis were identified. Demographic and clinical outcome data were abstracted through a review of electronic medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Records for 121 patients with gynecologic cancer and COVID\u201019 were abstracted; the median age at the COVID\u201019 diagnosis was 64.0 years (interquartile range, 51.0\u201073.0 years). Sixty\u2010six of the 121 patients (54.5%) required hospitalization; among the hospitalized patients, 45 (68.2%) required respiratory intervention, 20 (30.3%) were admitted to the intensive care unit, and 9 (13.6%) underwent invasive mechanical ventilation. Seventeen patients (14.0%) died of COVID\u201019 complications. No patient requiring mechanical ventilation survived. On multivariable analysis, hospitalization was associated with an age \u226564 years (risk ratio [RR], 1.73; 95% confidence interval [CI], 1.18\u20102.51), African American race (RR, 1.56; 95% CI, 1.13\u20102.15), and 3 or more comorbidities (RR, 1.43; 95% CI, 1.03\u20101.98). Only recent immunotherapy use (RR, 3.49; 95% CI, 1.08\u201011.27) was associated with death due to COVID\u201019 on multivariable analysis; chemotherapy treatment and recent major surgery were not predictive of COVID\u201019 severity or mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The case fatality rate among gynecologic oncology patients with a COVID\u201019 infection is 14.0%. Recent immunotherapy use is associated with an increased risk of mortality related to COVID\u201019 infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>The case fatality rate among gynecologic oncology patients with a coronavirus disease 2019 (COVID\u201019) infection is 14.0%; there is no association between cytotoxic chemotherapy and cancer\u2010directed surgery and COVID\u201019 severity or death.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>As such, patients can be counseled regarding the safety of continued anticancer treatments during the pandemic. This is important because the ability to continue cancer therapies for cancer control and cure is critical.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33084","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T03:07:05Z","timestamp":1596078425000},"page":"4294-4303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["COVID\u201019 outcomes of patients with gynecologic cancer in New York City"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3540-5804","authenticated-orcid":false,"given":"Olivia D.","family":"Lara","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Perlmutter Cancer Center NYU Langone Health New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roisin E.","family":"O\u2019Cearbhaill","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Perlmutter Cancer Center NYU Langone Health New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9816-9549","authenticated-orcid":false,"given":"Megan E.","family":"Sutter","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Perlmutter Cancer Center NYU Langone Health New York New York"},{"name":"Department of Population Health NYU Langone Health New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Knisely","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Physicians and Surgeons Columbia University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"McEachron","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology State University of New York Downstate Medical Center Brooklyn New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa R.","family":"Gabor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology and Women's Health Montefiore Medical Center and Albert Einstein College of Medicine Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Jee","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E.","family":"Fehniger","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Perlmutter Cancer Center NYU Langone Health New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Chun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology State University of New York Downstate Medical Center Brooklyn New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara S.","family":"Isani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology and Women's Health Montefiore Medical Center and Albert Einstein College of Medicine Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Physicians and Surgeons Columbia University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavana","family":"Pothuri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Perlmutter Cancer Center NYU Langone Health New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30251-8"},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization.WHO Coronavirus Disease (COVID\u201019) Dashboard. 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