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The Center for International Blood and Marrow Transplant Research (CIBMTR) database registered 15,999 patients with MM in the United States within 12 months of diagnosis during 2013 through 2017; a total of 2092 patients were aged \u226570 years. Nonrecurrence mortality (NRM), disease recurrence and\/or progression (relapse; REL), progression\u2010free survival (PFS), and overall survival (OS) were modeled using Cox proportional hazards models with age at transplantation as the main effect. Because of the large sample size, a <jats:italic>P<\/jats:italic> value &lt;.01 was considered to be statistically significant a priori.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An increase in AHCT was noted in 2017 (28%) compared with 2013 (15%) among patients aged \u226570 years. Although approximately 82% of patients received melphalan (Mel) at a dose of 200 mg\/m<jats:sup>2<\/jats:sup> overall, 58% of the patients aged \u226570 years received Mel at a dose of 140 mg\/m<jats:sup>2<\/jats:sup>. On multivariate analysis, patients aged \u226570 years demonstrated no difference with regard to NRM (hazard ratio [HR] 1.3; 99% confidence interval [99% CI], 1\u20101.7 [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.06]), REL (HR, 1.03; 99% CI, 0.9\u20101.1 [<jats:italic>P<\/jats:italic>\u00a0=\u00a00.6]), PFS (HR, 1.06; 99% CI, 1\u20101.2 [<jats:italic>P<\/jats:italic>\u00a0=\u00a00.2]), and OS (HR, 1.2; 99% CI, 1\u20101.4 [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02]) compared with the reference group (those aged 60\u201069 years). In patients aged \u226570 years, Mel administered at a dose of 140 mg\/m<jats:sup>2<\/jats:sup> was found to be associated with worse outcomes compared with Mel administered at a dose of 200 mg\/m<jats:sup>2<\/jats:sup>, including day 100 NRM (1% [95% CI, 1%\u20102%] vs 0% [95% CI, 0%\u20101%]; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003]), 2\u2010year PFS (64% [95% CI, 60%\u201067%] vs 69% [95% CI, 66%\u201073%]; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003), and 2\u2010year OS (85% [95% CI, 82%\u201087%] vs 89% [95% CI, 86%\u201091%]; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01]), likely representing frailty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of the current study demonstrated that AHCT remains an effective consolidation therapy among patients with MM across all age groups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33171","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T10:59:57Z","timestamp":1600858797000},"page":"5077-5087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Age no bar: A CIBMTR analysis of elderly patients undergoing autologous hematopoietic cell transplantation for multiple myeloma"],"prefix":"10.1002","volume":"126","author":[{"given":"Pashna N.","family":"Munshi","sequence":"first","affiliation":[{"name":"MedStar Georgetown University Hospital Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Vesole","sequence":"additional","affiliation":[{"name":"John Theurer Cancer Center Hackensack University Medical Center Hackensack New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Jurczyszyn","sequence":"additional","affiliation":[{"name":"Medicini Department of Hematology Jagiellonian University Medical College Krakow Poland"},{"name":"Krakow Branch Polish Society of Haematology and Blood Transfusion Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Maciej","family":"Zaucha","sequence":"additional","affiliation":[{"name":"Department of Hematology and Transplantology Medical University of Gdansk Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"St. Martin","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Davila","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhav","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif M.","family":"Badawy","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Stem Cell Transplant Ann and Robert H. 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