{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:47:01Z","timestamp":1790761621009,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["2KL2TR002457"],"award-info":[{"award-number":["2KL2TR002457"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Socioeconomic and demographic categories such as income, race, insurance status, and treatment center type are associated with outcomes in acute leukemia. This study was aimed at determining whether the distance to treatment center affects overall survival for children and young adults with acute leukemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The National Cancer Database was queried for patients 39 years old or younger who were diagnosed with acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL). A backward elimination procedure was used to select final multivariate Cox models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 12,301 patients with AML and 22,683 patients with ALL were analyzed. The ALL model included distance to treatment center, Charlson\u2010Deyo score, age, race, insurance status, and community income level. US census definitions of\n                      <jats:italic>urban<\/jats:italic>\n                      and\n                      <jats:italic>rural<\/jats:italic>\n                      were not statistically significant, and no interaction was significant for included variables. Compared with distances &gt; 50 miles, all other distances were associated with improved survival (hazard ratio [HR] for \u226410 miles, 0.91;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.04; HR for &gt;10 to \u226420 miles, 0.86;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.004; HR for &gt;20 to \u226450 miles, 0.87;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.005). The final model for AML included the same variables as the ALL model except for distance to treatment center, which was not statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For children and young adults with ALL, distances &gt; 50 miles are associated with inferior overall survival; however, no difference is seen for AML. Although it is unknown whether differences in survival for patients with ALL based on distance are driven by relapse or treatment\u2010related mortality, increased attention to adherence, supportive care, and logistics for patients traveling long distances is warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay Summary<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>For children and young adults with acute lymphoblastic leukemia, living more than 50 miles from the treatment center is associated with worse outcomes.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3225-7129","authenticated-orcid":false,"given":"Stefanie M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Oncology, and Blood and Marrow Transplantation Pediatric Institute Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabi","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Oncology, and Blood and Marrow Transplantation Pediatric Institute Cleveland Clinic Cleveland 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