{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:29:26Z","timestamp":1787671766015,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH K12 Career Development Award"],"award-info":[{"award-number":["NIH K12 Career Development Award"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In a recent trial, a 6\u2010session intervention (BMT\u2010CARE) integrating medical information with cognitive\u2010behavioral strategies improved quality of life (QOL), mood, coping skills, and self\u2010efficacy for family\/friend caregivers of hematopoietic stem cell transplantation (HCT) recipients. This study examined whether improvements in coping and self\u2010efficacy mediated the intervention effects on QOL and mood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From December 2017 to April 2019, 100 caregivers of HCT recipients were enrolled into a randomized clinical trial of BMT\u2010CARE versus usual care. Caregivers completed self\u2010report measures of QOL (CareGiver Oncology Quality of Life questionnaire), depression and anxiety symptoms (Hospital Anxiety and Depression Scale), coping skills (Measure of Current Status), and self\u2010efficacy (Cancer Self\u2010Efficacy Scale\u2013Transplant) at enrollment (before HCT) and 60\u00a0days after HCT. Causal mediation regression models were used to examine whether changes in coping and self\u2010efficacy mediated intervention effects on QOL as well as depression and anxiety symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Improvements in 60\u2010day QOL in patients assigned to BMT\u2010CARE were partially mediated by improved coping and self\u2010efficacy (indirect effect, 6.93; SE, 1.85; 95% CI, 3.71\u201011.05). Similarly, reductions in 60\u2010day depression and anxiety symptoms were partially mediated by improved coping and self\u2010efficacy (indirect effect for depression, \u22121.19; SE, 0.42; 95% CI, \u22122.23 to \u22120.53; indirect effect for anxiety, \u22121.46; SE, 0.55; 95% CI, \u22122.52 to \u22120.43). Combined improvements in coping and self\u2010efficacy accounted for 67%, 80%, and 39% of the total intervention effects on QOL and depression and anxiety symptoms, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Coping and self\u2010efficacy are essential components of a brief psychosocial intervention that improves QOL and mood for caregivers of HCT recipients during the acute recovery period.<\/jats:p><\/jats:sec><jats:sec><jats:title>LAY SUMMARY<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>A 6\u2010session program (BMT\u2010CARE) focused on providing medical information, caregiving skills, and self\u2010care and coping strategies has been previously reported to improve the quality of life and mood of caregivers of hematopoietic stem cell transplantation recipients in comparison with caregivers who receive care as usual.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Using statistical models, this study suggests that learning coping skills and improving self\u2010efficacy are the most essential components of this program that likely lead to better quality of life and mood for caregivers.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33191","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T13:53:13Z","timestamp":1602078793000},"page":"5337-5346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Enhanced coping and self\u2010efficacy in caregivers of stem cell transplant recipients: Identifying mechanisms of a multimodal psychosocial intervention"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9740-624X","authenticated-orcid":false,"given":"Jamie M.","family":"Jacobs","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital Boston Massachusetts"},{"name":"Harvard Medical 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