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This study used the Center for International Blood and Marrow Transplant Research (CIBMTR) database to examine the impact of t(11;14) on the clinical outcomes of patients with MM of African American and White descent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study evaluated 3538 patients who underwent autologous hematopoietic cell transplantation (autoHCT) for MM from 2008 to 2016 and were reported to the CIBMTR. Patients were analyzed in 4 groups: African Americans with t(11;14) (n = 117), African Americans without t(11;14) (n = 968), Whites with t(11;14) (n = 266), and Whites without t(11;14) (n = 2187).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>African Americans with t(11;14) were younger, had lower Karnofsky scores, and had more advanced stage MM with a higher Hematopoietic Cell Transplantation\u2013Comorbidity Index (HCT\u2010CI). Fewer African Americans with t(11;14) (21%) had a coexistent high\u2010risk marker in comparison with Whites with t(11;14) (27%). In a multivariate analysis, race and t(11;14) had no association with progression\u2010free survival. However, overall survival was superior among African Americans with t(11;14) in comparison with Whites with t(11;14) (hazard ratio, 0.53; 95% confidence interval, 0.30\u20100.93; <jats:italic>P<\/jats:italic> = .03). Survival was also associated with female sex, stage, time from diagnosis to transplant, a low HCT\u2010CI, and receipt of maintenance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Race may have a differential impact on the survival of patients with t(11;14) MM who undergo autoHCT and needs to be further studied.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33208","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T12:53:11Z","timestamp":1600865591000},"page":"82-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["African Americans with translocation t(11;14) have superior survival after autologous hematopoietic cell transplantation for multiple myeloma in comparison with Whites in the United States"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1548-918X","authenticated-orcid":false,"given":"Talha","family":"Badar","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parameswaran","family":"Hari","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research Department of Medicine Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"D\u00e1vila","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research Department of Medicine Medical College of Wisconsin Milwaukee 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Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar O.","family":"Freytes","sequence":"additional","affiliation":[{"name":"Texas Transplant Institute San Antonio Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar","family":"Rodriguez Valdes","sequence":"additional","affiliation":[{"name":"Wake Forest Baptist Health Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Lee","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Vesole","sequence":"additional","affiliation":[{"name":"John Theurer Cancer Center Hackensack University Medical Center Hackensack New 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