{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:50:13Z","timestamp":1790484613103,"version":"4.1.0"},"reference-count":153,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>During the period from 1942 to 1962, treatment attempts with single\u2010agent chemotherapy such as nitrogen mustard and urethan gained limited application. However, the groundbreaking success with aminopterin in the treatment of patients with pediatric acute leukemia and methotrexate in the treatment of gestational choriocarcinoma established single\u2010agent chemotherapy as a pioneering contribution to oncology. The landmark discovery that early\u2010stage Hodgkin disease is curable with radiation made radiotherapy into an essential specialty of oncology. Although radical surgical treatment dominated the field of surgery, the excision of localized cancers with or without adjuvant radiation emerged as new modality in therapy. Cytopathology and surgical pathology became new fields in medicine and pathologists became an integral part of the preoperative, intraoperative, and postoperative care of patients with cancer. The discovery of multiple new drugs demonstrated promising results and widened the field of oncology from the laboratory to the clinic. In the etiology of cancer, precancerous conditions were named and carcinoma of the lung was definitively linked to cigarette smoking. All things considered, the progress made between 1942 and 1962 came about through the dedicated work of many individuals. However, there were 7 distinguished pathfinders (2 pathologists, 1 pediatric pathologist\u2013oncologist, 1 radiation therapist, 1 physician\u2010actuary, 1 gynecologist\u2010oncologist, and 1 chemist) who, despite their different backgrounds, interests, and sex, made groundbreaking contributions to oncology.<\/jats:p>","DOI":"10.1002\/cncr.33223","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T13:38:41Z","timestamp":1603460321000},"page":"12-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pathfinders in oncology from the first clinical use of single\u2010agent chemotherapy to the introduction of mammography"],"prefix":"10.1002","volume":"127","author":[{"given":"Steven I.","family":"Hajdu","sequence":"first","affiliation":[{"name":"Pathology Consultants Westlake Village California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"e_1_2_4_2_1","volume-title":"The Cambridge World History of Human Diseases","author":"Kiple KE","year":"1999"},{"key":"e_1_2_4_3_1","volume-title":"The Timechart History of Medicine","author":"Davies G","year":"1999"},{"key":"e_1_2_4_4_1","volume-title":"Morton's Medical Biography","author":"Norman JM","year":"1991"},{"key":"e_1_2_4_5_1","volume-title":"Contrary to Nature","author":"Shimkin MB","year":"1977"},{"key":"e_1_2_4_6_1","volume-title":"Women in Medicine","author":"Garza H","year":"1996"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31135"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32086"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32839"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28319"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194204000-00014"},{"key":"e_1_2_4_12_1","first-page":"751","article-title":"Characteristics of a liposarcoma grown in vitro","volume":"19","author":"Murray MR","year":"1943","journal-title":"Am J Pathol"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/50.2.251"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198404000-00008"},{"key":"e_1_2_4_15_1","volume-title":"Human Cancer: Etiologic Factors, Precancerous Lesions, Growth Spread, Symptoms, Diagnosis, Prognosis, and Principles of Treatment","author":"Stout AP","year":"1932"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194207000-00004"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194309000-00014"},{"key":"e_1_2_4_18_1","first-page":"86","article-title":"Liposarcoma\u2013the malignant tumor of lipoblasts","volume":"119","author":"Stout AP","year":"1944","journal-title":"Ann Surg"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194603000-00011"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194802000-00007"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196203\/04)15:2<400::AID-CNCR2820150224>3.0.CO;2-P"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196303)16:3<331::AID-CNCR2820160307>3.0.CO;2-F"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196411)17:11<1445::AID-CNCR2820171112>3.0.CO;2-G"},{"key":"e_1_2_4_24_1","first-page":"585","article-title":"Demonstration of the formation of reticulin by Schwannian tumor cells in vitro","volume":"18","author":"Murray MR","year":"1942","journal-title":"Am J Pathol"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194412000-00004"},{"key":"e_1_2_4_26_1","first-page":"898","article-title":"The classification and diagnosis of human tumors by tissue culture methods","volume":"12","author":"Murray MR","year":"1954","journal-title":"Tex Rep Biol Med"},{"key":"e_1_2_4_27_1","first-page":"453","article-title":"Recent observations on mesenchymal tumours in adults and children","volume":"88","author":"Stout AP","year":"1963","journal-title":"Canadian Med Assoc J"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194311810-00005"},{"key":"e_1_2_4_29_1","first-page":"52","article-title":"Nomenclature des cancers","volume":"1","author":"Denoix PF","year":"1944","journal-title":"Bull Inst Natl Hyg"},{"key":"e_1_2_4_30_1","volume-title":"Concerning the \u201cdiversity\u201d of certain cancers: based on 33,784 observations of cancers of the breast, cervix uteri, tongue, skin, larynx, esophagus, and rectum. French Ministry of Public Health National Institute of Hygiene Monograph 4","author":"Denoix PF","year":"1954"},{"key":"e_1_2_4_31_1","first-page":"849","article-title":"Principle of excision and dissection in continuity for primary and metastatic melanoma of skin","volume":"17","author":"Pack GT","year":"1945","journal-title":"Surgery"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)70130-9"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.103.2675.409"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1946.02870380008004"},{"key":"e_1_2_4_35_1","first-page":"421","article-title":"Electron microscope study of chicken tumor cells","volume":"7","author":"Claude A","year":"1947","journal-title":"Cancer Res"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(47)90445-6"},{"key":"e_1_2_4_37_1","first-page":"585","article-title":"Endothelial\u2010cell sarcoma of liver following thorotrast injections","volume":"23","author":"MacMahon HE","year":"1947","journal-title":"Am J Pathol"},{"key":"e_1_2_4_38_1","first-page":"431","article-title":"Some morphological features of cultured rat sarcoma cells as revealed by the electron microscope","volume":"7","author":"Porter KR","year":"1947","journal-title":"Cancer Res"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194805)1:1<3::AID-CNCR2820010103>3.0.CO;2-7"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/18.2.104"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194807)1:2<177::AID-CNCR2820010203>3.0.CO;2-A"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194805)1:1<64::AID-CNCR2820010105>3.0.CO;2-W"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194511000-00005"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-21-252-599"},{"key":"e_1_2_4_45_1","first-page":"1","article-title":"Studies in the incidence of cancers in a factory handling inorganic compounds of arsenic","volume":"5","author":"Hill AB","year":"1948","journal-title":"Br J Ind Med"},{"key":"e_1_2_4_46_1","first-page":"591","article-title":"Melanomas of childhood","volume":"24","author":"Spitz S","year":"1948","journal-title":"Am J Pathol"},{"key":"e_1_2_4_47_1","first-page":"129","article-title":"Sidney Farber, MD, 1903\u20101973","volume":"77","author":"Bailey OT","year":"1974","journal-title":"Am J Pathol"},{"key":"e_1_2_4_48_1","volume-title":"The Emperor of All Maladies: A Biography of Cancer","author":"Mukherjee S","year":"2010"},{"key":"e_1_2_4_49_1","volume-title":"The Postmortem Examination","author":"Farber S","year":"1937"},{"key":"e_1_2_4_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM194806032382301"},{"key":"e_1_2_4_51_1","first-page":"582","article-title":"Carcinolytic action of antibiotics: puromycin and actinomycin D","volume":"31","author":"Farber S","year":"1955","journal-title":"Am J Pathol"},{"key":"e_1_2_4_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1960.tb20165.x"},{"key":"e_1_2_4_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60721-6"},{"key":"e_1_2_4_54_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.15.1.14"},{"key":"e_1_2_4_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194911)2:6<943::AID-CNCR2820020602>3.0.CO;2-P"},{"key":"e_1_2_4_56_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.v15i5.285"},{"key":"e_1_2_4_57_1","first-page":"299","article-title":"A study of survival in Hodgkin's disease treated radiologically","volume":"63","author":"Peters MV","year":"1950","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"e_1_2_4_58_1","first-page":"114","article-title":"A study of Hodgkin's disease treated by irradiation","volume":"79","author":"Peters MV","year":"1958","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"e_1_2_4_59_1","first-page":"1232","article-title":"Prophylactic treatment of adjacent areas in Hodgkin's disease","volume":"26","author":"Peters MV","year":"1966","journal-title":"Cancer Res"},{"key":"e_1_2_4_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.223.1.53"},{"key":"e_1_2_4_61_1","first-page":"32","article-title":"Carcinoma of the breast with particular reference to preoperative radiation","volume":"4","author":"Peters MV","year":"1953","journal-title":"J Can Assoc Radiol"},{"key":"e_1_2_4_62_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1965.03080010034008"},{"key":"e_1_2_4_63_1","first-page":"163","article-title":"Radiation therapy in the management of breast cancer","volume":"6","author":"Peters MV","year":"1970","journal-title":"Proc Natl Cancer Conf"},{"key":"e_1_2_4_64_1","first-page":"186","article-title":"Cutting the \u201cGordian knot\u201d in early breast cancer","volume":"8","author":"Peters MV","year":"1975","journal-title":"Ann R Coll Physicians Surg Can"},{"key":"e_1_2_4_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(77)90124-9"},{"key":"e_1_2_4_66_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1950.02910390001001"},{"key":"e_1_2_4_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj210"},{"key":"e_1_2_4_68_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-OBIT"},{"key":"e_1_2_4_69_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbm.2010.0019"},{"key":"e_1_2_4_70_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4682.739"},{"key":"e_1_2_4_71_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4797.1271"},{"key":"e_1_2_4_72_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4877.1451"},{"key":"e_1_2_4_73_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38142.554479.AE"},{"key":"e_1_2_4_74_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.32.4.303"},{"key":"e_1_2_4_75_1","first-page":"78","article-title":"A note from history. The use of tobacco","volume":"40","author":"Hajdu SI","year":"2010","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_4_76_1","first-page":"81","article-title":"Mortality from lung cancer in asbestos workers","volume":"12","author":"Doll R","year":"1955","journal-title":"Br J Ind Med"},{"key":"e_1_2_4_77_1","first-page":"394","article-title":"Mortality of gas workers","volume":"29","author":"Doll R","year":"1972","journal-title":"Br J Ind Med"},{"key":"e_1_2_4_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<86::AID-CNCR2820030112>3.0.CO;2-Y"},{"key":"e_1_2_4_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18003815005"},{"key":"e_1_2_4_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195107)4:4<697::AID-CNCR2820040407>3.0.CO;2-8"},{"key":"e_1_2_4_81_1","first-page":"621","article-title":"Essai de traitement des leucemies aigues de l'enfance par l'association aminopterin\u2010cortison","volume":"16","author":"Bernard J","year":"1951","journal-title":"Bull Mem Soc Med Hopitaux"},{"key":"e_1_2_4_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195111)4:6<1263::AID-CNCR2820040613>3.0.CO;2-6"},{"key":"e_1_2_4_83_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195110112451502"},{"key":"e_1_2_4_84_1","first-page":"316","article-title":"The stereotactic method and radiosurgery of the brain","volume":"102","author":"Leksell L","year":"1951","journal-title":"Acta Chir Scand"},{"key":"e_1_2_4_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195201)5:1<100::AID-CNCR2820050112>3.0.CO;2-K"},{"key":"e_1_2_4_86_1","first-page":"13","article-title":"Lymphangiography in man; a method of outlining lymphatic trunk at operation","volume":"11","author":"Kinmonth JB","year":"1952","journal-title":"Clin Sci"},{"key":"e_1_2_4_87_1","volume-title":"Tumors of the Lower Respiratory Tract","author":"Liebow AA","year":"1952"},{"key":"e_1_2_4_88_1","first-page":"329","article-title":"Bronchiolo\u2010alveolar carcinoma","volume":"10","author":"Liebow AA","year":"1960","journal-title":"Adv Intern Med"},{"key":"e_1_2_4_89_1","first-page":"838","article-title":"Attempts to isolate the active agent in Cysticercus Fasciolaris","volume":"13","author":"Dunning WF","year":"1953","journal-title":"Cancer Res"},{"key":"e_1_2_4_90_1","first-page":"40","article-title":"Localization of brain tumors with positron emitters","volume":"11","author":"Brownell GL","year":"1953","journal-title":"Nucleonics"},{"key":"e_1_2_4_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(53)90885-X"},{"key":"e_1_2_4_92_1","first-page":"275","volume-title":"Guiding the Surgeon's Hand","author":"Ackerman LV","year":"1997"},{"key":"e_1_2_4_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931201)72:11<3137::AID-CNCR2820721102>3.0.CO;2-R"},{"key":"e_1_2_4_94_1","first-page":"434","article-title":"In memoriam Prof. Lauren V. Ackerman","volume":"81","author":"Contesso G","year":"1994","journal-title":"Bull Cancer"},{"key":"e_1_2_4_95_1","first-page":"111","volume-title":"Guiding the Surgeon's Hand","author":"Dehner LP","year":"1997"},{"key":"e_1_2_4_96_1","volume-title":"Cancer: Diagnosis, Treatment and Prognosis","author":"Ackerman LV","year":"1947"},{"key":"e_1_2_4_97_1","first-page":"670","article-title":"Verrucous carcinoma of the oral cavity","volume":"23","author":"Ackerman LV","year":"1948","journal-title":"Surgery"},{"key":"e_1_2_4_98_1","volume-title":"Neoplastic Diseases","author":"Ewing J","year":"1940"},{"key":"e_1_2_4_99_1","volume-title":"Surgical Pathology","author":"Ackerman LV","year":"1953"},{"key":"e_1_2_4_100_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V9.8.824.824"},{"key":"e_1_2_4_101_1","first-page":"465","article-title":"Acinic cell adenocarcinoma of the parotid gland","volume":"300","author":"Godwin JT","year":"1954","journal-title":"Am J Pathol"},{"key":"e_1_2_4_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1955.36"},{"key":"e_1_2_4_103_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1955.02960210163023"},{"key":"e_1_2_4_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1955)8:2<302::AID-CNCR2820080209>3.0.CO;2-W"},{"key":"e_1_2_4_105_1","first-page":"612","article-title":"Defect of neuromuscular conduction associated with malignant neoplasms","volume":"187","author":"Lambert EH","year":"1956","journal-title":"Am J Physiol"},{"key":"e_1_2_4_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195607\/08)9:4<792::AID-CNCR2820090429>3.0.CO;2-B"},{"key":"e_1_2_4_107_1","first-page":"2764","article-title":"Min Chiu Li: a perspective in cancer therapy","volume":"8","author":"Freireich EJ","year":"2002","journal-title":"Clin Cancer Res"},{"key":"e_1_2_4_108_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-93-22757"},{"key":"e_1_2_4_109_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1960.03030100059013"},{"key":"e_1_2_4_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)33879-2"},{"key":"e_1_2_4_111_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1977.03270360034009"},{"key":"e_1_2_4_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(79)90357-0"},{"key":"e_1_2_4_113_1","volume-title":"Tumeurs Humaines","author":"Masson P","year":"1956"},{"key":"e_1_2_4_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1957.43"},{"key":"e_1_2_4_115_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195709122571102"},{"key":"e_1_2_4_116_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195701172560301"},{"key":"e_1_2_4_117_1","volume-title":"Bone Tumors. General Aspects and Analysis of 2,276 Cases","author":"Dahlin DC","year":"1957"},{"key":"e_1_2_4_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004619704"},{"key":"e_1_2_4_119_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-9-961"},{"key":"e_1_2_4_120_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbm.2007.0051"},{"key":"e_1_2_4_121_1","first-page":"51","article-title":"A lifetime quest for a cure","author":"McDowell JL","year":"2002","journal-title":"Mod Drug Discov"},{"key":"e_1_2_4_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)56194-9"},{"key":"e_1_2_4_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)77771-0"},{"key":"e_1_2_4_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01122a037"},{"key":"e_1_2_4_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1954.tb40009.x"},{"key":"e_1_2_4_126_1","first-page":"802","article-title":"Uracil antagonism and inhibition of mammary adenocarcinoma 755","volume":"18","author":"Elion GB","year":"1958","journal-title":"Cancer Res"},{"key":"e_1_2_4_127_1","first-page":"1207","article-title":"Relationship between metabolic fate and antitumor activities of thiopurines","volume":"23","author":"Elion GB","year":"1963","journal-title":"Cancer Res"},{"key":"e_1_2_4_128_1","first-page":"4082","article-title":"Combination chemotherapy in vitro exploiting glutamine metabolism of human glioma and medulloblastoma","volume":"45","author":"Dranoff G","year":"1985","journal-title":"Cancer Res"},{"issue":"24","key":"e_1_2_4_129_1","first-page":"6917","article-title":"Establishment of a melphalan\u2010resistant rhabdomyosarcoma xenograft with cross\u2010resistance to vincristine and enhanced sensitivity following buthionine sulfoximine\u2013mediated glutathione depletion","volume":"49","author":"Rosenberg MC","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_4_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050848"},{"key":"e_1_2_4_131_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.199"},{"key":"e_1_2_4_132_1","first-page":"898","article-title":"Symposium on immunosuppressive drugs. Biochemistry and pharmacology of purine analogues","volume":"26","author":"Elion GB","year":"1967","journal-title":"Fed Proc"},{"key":"e_1_2_4_133_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar50019a002"},{"key":"e_1_2_4_134_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.34.2.560-568.1980"},{"key":"e_1_2_4_135_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/20.6.1223"},{"key":"e_1_2_4_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(58)91905-6"},{"key":"e_1_2_4_137_1","first-page":"963","article-title":"The principle and technique of resection of soft parts for sarcoma","volume":"44","author":"Bowden L","year":"1958","journal-title":"Surgery"},{"key":"e_1_2_4_138_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1958.00260140111016"},{"key":"e_1_2_4_139_1","first-page":"1157","article-title":"Uterine\u2010cancer morbidity in New York City and its relation to pattern of regional variation within the United States","volume":"22","author":"Haenszel W","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_4_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195911\/12)12:6<1092::AID-CNCR2820120606>3.0.CO;2-V"},{"key":"e_1_2_4_141_1","first-page":"9","article-title":"Clinical pharmacology and preliminary evaluation of Cytoxan (cyclophosphamide)","volume":"3","author":"Coggins PR","year":"1959","journal-title":"Cancer Chemother Rep"},{"key":"e_1_2_4_142_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.46.3.365"},{"key":"e_1_2_4_143_1","first-page":"1197","article-title":"A minute chromosome in human chronic granulocytic leukemia","volume":"132","author":"Nowell PC","year":"1960","journal-title":"Science"},{"key":"e_1_2_4_144_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/24.3.551"},{"key":"e_1_2_4_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196001\/02)13:1<77::AID-CNCR2820130114>3.0.CO;2-D"},{"key":"e_1_2_4_146_1","doi-asserted-by":"publisher","DOI":"10.1148\/74.5.834"},{"key":"e_1_2_4_147_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196112000-00026"},{"key":"e_1_2_4_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1956.tb32134.x"},{"key":"e_1_2_4_149_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1961.63040260015013a"},{"key":"e_1_2_4_150_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-107-26576"},{"key":"e_1_2_4_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)65058-4"},{"key":"e_1_2_4_152_1","volume-title":"Cytopathology of Sarcomas and Other Nonepithelial Malignant Tumors","author":"Hajdu SI","year":"1976"},{"key":"e_1_2_4_153_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/3.6.579"},{"key":"e_1_2_4_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23707"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.33223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.33223","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.33223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:16:28Z","timestamp":1760274988000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.33223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,23]]},"references-count":153,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/cncr.33223"],"URL":"https:\/\/doi.org\/10.1002\/cncr.33223","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,23]]},"assertion":[{"value":"2020-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}