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This study was aimed at characterizing genetic variation related to adult body mass index (BMI) among survivors of childhood ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Genetic associations of BMI among 1458 adult survivors of childhood ALL (median time from diagnosis, 20 years) were analyzed by multiple approaches. A 2\u2010stage genome\u2010wide association study in the Childhood Cancer Survivor Study (CCSS) and the St. Jude Lifetime Cohort Study (SJLIFE) was performed. BMI was a highly polygenic trait in the general population. Within the known loci, the BMI percent variance explained was estimated, and additive interactions (chi\u2010square test) with CRT in the CCSS were evaluated. The role of DNA methylation in CRT interaction was further evaluated in a subsample of ALL survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a meta\u2010analysis of the CCSS and SJLIFE, 2 novel loci associated with adult BMI among survivors of childhood ALL (<jats:italic>LINC00856<\/jats:italic> rs575792008 and <jats:italic>EMR1<\/jats:italic> rs62123082; <jats:italic>P<\/jats:italic><jats:sub>Meta<\/jats:sub> &lt; 5E\u20138) were identified. It was estimated that the more than 700 known loci explained 6.2% of the variation in adult BMI in childhood ALL survivors. Within the known loci, significant main effects for 23 loci and statistical interactions with CRT at 9 loci (<jats:italic>P<\/jats:italic> &lt; 7.0E\u20135) were further identified. At 2 CRT\u2010interacting loci, DNA methylation patterns may have differed by age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adult survivors of childhood ALL have genetic heritability for BMI similar to that observed in the general population. This study provides evidence that treatment with CRT can modify the effect of genetic variants on adult BMI in childhood ALL survivors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33258","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T13:45:06Z","timestamp":1602596706000},"page":"310-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Genetic variation in the body mass index of adult survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-9860","authenticated-orcid":false,"given":"Melissa A.","family":"Richard","sequence":"first","affiliation":[{"name":"Section of Hematology\/Oncology Department of Pediatrics Texas Children's Cancer Center and Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5802-5073","authenticated-orcid":false,"given":"Austin L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Section of Hematology\/Oncology Department of Pediatrics Texas Children's Cancer Center and Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Belmont","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Scheurer","sequence":"additional","affiliation":[{"name":"Section of Hematology\/Oncology Department of Pediatrics Texas Children's Cancer Center and Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidal M.","family":"Arroyo","sequence":"additional","affiliation":[{"name":"Section of Hematology\/Oncology Department of Pediatrics Texas Children's Cancer Center and Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayla L.","family":"Foster","sequence":"additional","affiliation":[{"name":"Section of Hematology\/Oncology Department of Pediatrics Texas Children's Cancer Center and Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen D.","family":"Kern","sequence":"additional","affiliation":[{"name":"Section of Hematology\/Oncology Department of Pediatrics Texas Children's Cancer Center and Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa M.","family":"Hudson","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital Memphis Tennessee"},{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7405-0906","authenticated-orcid":false,"given":"Wendy M.","family":"Leisenring","sequence":"additional","affiliation":[{"name":"Clinical Research and Public Health Sciences Divisions Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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