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Cardiovascular risk factors included waist circumference, hypertension, high cholesterol, and type 2 diabetes. Obesity\u2010related cancers included breast cancer, colorectal cancer, endometrial cancer, kidney cancer, pancreatic cancer, ovarian cancer, stomach cancer, liver cancer, and non\u2010Hodgkin lymphoma. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for important predictors of survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a median follow\u2010up of 10.0 years from the date of the cancer diagnosis, there were 3607 total deaths, with 1546 (43%) due to cancer. Most participants (62.9%) had 1 or 2 cardiometabolic risk factors, and 8.1% had 3 or 4. In adjusted models, women with 3 to 4 risk factors (vs none) had a higher risk of all\u2010cause mortality (HR, 1.99; 95% CI, 1.73\u20102.30), death due to cardiovascular disease (CVD) (HR, 4.01; 95% CI, 2.88\u20105.57), cancer\u2010specific mortality (HR, 1.37; 95% CI, 1.1\u20101.72), and other\u2010cause mortality (HR, 2.14; 95% CI, 1.70\u20102.69). A higher waist circumference was associated with greater all\u2010cause mortality (HR, 1.17; 95% CI, 1.06\u20101.30) and cancer\u2010specific mortality (HR, 1.22; 95% CI, 1.04\u20101.42).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among postmenopausal women diagnosed with cancer in the WHI, cardiometabolic risk factors before the cancer diagnosis were associated with greater all\u2010cause, CVD, cancer\u2010specific, and other\u2010cause mortality. These results raise hypotheses regarding potential clinical intervention strategies targeting cardiometabolic abnormalities that require future prospective studies for confirmation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>This study uses information from the Women's Health Initiative (WHI) to find out whether cardiac risk factors are related to a greater risk of dying among older women with cancer. The WHI is the largest study of medical problems faced by older women in this country.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>The results show that women who have 3 or 4 risk factors are more likely to die of any cause, heart disease, or cancer in comparison with women with no risk factors.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>It is concluded that interventions to help to lower the burden of cardiac risk factors can have an important impact on survivorship among women with cancer.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33295","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T09:28:31Z","timestamp":1604568511000},"page":"598-608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Cardiometabolic risk factors and survival after cancer in the Women's Health 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